Benzo(a)pyrene

cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens







32 Article(s)
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1 31112310 Micronuclei Formation by Promutagens in Metabolism-Incompetent V79 Cells Interacting With Activation-Proficient Cells in Various Experimental Settings. 2020 Feb 3
2 30122317 Conditionally reprogrammed human normal bronchial epithelial cells express comparable levels of cytochromes p450 and are sensitive to BaP induction. 2018 Sep 10 1
3 26552516 Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method. 2016 Jan 4
4 23626760 Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes. 2013 2
5 19919601 Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. 2010 Jan 2
6 19961320 Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. 2010 May 1
7 20542099 Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells. 2010 Sep 1 1
8 19202560 Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. 2009 Jan-Feb 2
9 19406224 Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology. 2009 Aug 1
10 19501186 In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation. 2009 Jun-Jul 1
11 19590965 Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. 2009 Sep 1
12 18372000 Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. 2008 Jul 15 3
13 17261025 Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites. 2007 Mar 1 1
14 16773535 Induction of CYP1A by green tea extract in human intestinal cell lines. 2006 May 1
15 16970932 Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells. 2006 Nov 7 2
16 14729370 Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes. 2004 Feb 14 3
17 14743400 Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells. 2004 Feb 1 1
18 9152602 Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. 1997 May 1
19 7581497 Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells. 1995 1
20 1654865 Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180. 1991 Oct 4
21 2351129 Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content. 1990 Jun 1
22 3143724 Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line. 1988 Dec 15 1
23 3684951 The metabolism of 2,5-diphenyloxazole (PPO) in human lymphocytes and rat liver microsomes. 1987 Sep 1
24 3011254 Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin. 1986 Jul 1
25 4015401 Covalent binding of BP-metabolites to DNA of cultured human hair follicle keratinocytes. 1985 Apr 1
26 4077222 Presence of cytochrome P-450-dependent monooxygenase in intimal cells of the hog aorta. 1985 Nov-Dec 1
27 6477826 Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonis detergens (coal tar). 1984 Sep 1
28 7056021 Absence of seasonal variation in antipyrine metabolism. 1982 Feb 2
29 7333581 Expression of aromatic polycyclic hydrocarbon-induced monooxygenase (aryl hydrocarbon hydroxylase) in man x mouse hybrids is associated with human chromosome 2. 1981 1
30 697921 Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity. 1978 1
31 711851 Human skin aryl hydrocarbon hydroxylase. Induction by coal tar. 1978 Nov 2
32 1026852 The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes. 1976 1