Title : Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites.

Pub. Date : 2007 Mar 1

PMID : 17261025






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1 Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 > CYP1A2 > CYP1A1 > CYP2E1 > myoglobin, the same as the order of their metabolic activity. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 2 Homo sapiens