Tetradecanoylphorbol Acetate

Jun proto-oncogene, AP-1 transcription factor subunit ; Homo sapiens







233 Article(s)
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51 16480952 Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. 2006 Mar 31 6
52 16651411 Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway. 2006 May 1 4
53 16757545 Phorbol ester treatment of human myometrial cells suppresses expression of oxytocin receptor through a mechanism that does not involve activator protein-1. 2006 Nov 2
54 16940435 Regulation of c-jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase-1 (MNK1). 2006 Oct 1
55 17082637 A JNK-independent signaling pathway regulates TNF alpha-stimulated, c-Jun-driven FRA-1 protooncogene transcription in pulmonary epithelial cells. 2006 Nov 15 1
56 15806162 Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. 2005 Jun 16 1
57 15831482 Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites. 2005 May 1
58 15863510 Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. 2005 Jul 1 1
59 15034932 Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells. 2004 Apr 1 5
60 15047839 Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. 2004 Apr 10
61 15138488 JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). 2004 May 17 4
62 15139522 Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. 2004 Apr 2
63 15161022 EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells. 2004 Mar-Apr 1
64 15180304 Regulation of c-fos and c-jun gene expression by lipopolysaccharide and cytokines in primary cultured astrocytes: effect of PKA and PKC pathways. 2004 Apr 3
65 15279563 Regulation of MAO-A and MAO-B gene expression. 2004 Aug 1
66 15282324 Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. 2004 Aug 1
67 15289320 Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. 2004 Aug 1 5
68 15292277 The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun. 2004 Nov 4
69 15378003 A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function. 2004 Oct 28 1
70 12433930 Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator. 2003 Jan 24 3
71 12592382 ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. 2003 Feb 20 3
72 12651162 Regulation of trespin expression by modulators of cell growth, differentiation, and apoptosis in prostatic epithelial cells. 2003 Apr 1 1
73 12787135 17Beta-estradiol inhibits MCP-1 production in human keratinocytes. 2003 Jun 3
74 12925217 Histamine enhances the production of nerve growth factor in human keratinocytes. 2003 Sep 4
75 12947046 An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells. 2003 Dec 1
76 13679379 Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. 2003 Nov 28 2
77 14500826 hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure. 2003 Oct 1 3
78 14654785 c-Jun and the dominant-negative mutant, TAM67, induce vimentin gene expression by interacting with the activator Sp1. 2003 Dec 4 1
79 11914583 Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene. 2002 Mar-Apr 4
80 11950097 UVA irradiation-induced activation of activator protein-1 is correlated with induced expression of AP-1 family members in the human keratinocyte cell line HaCaT. 2002 Mar 1
81 11980644 Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. 2002 May 1 4
82 12072430 Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells. 2002 Aug 30 6
83 12076508 Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. 2002 Jul 7 2
84 12082627 Evidence that the human death receptor 4 is regulated by activator protein 1. 2002 May 9 6
85 12091247 BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. 2002 Jul 2
86 12187329 Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. 2002 Aug 1
87 12213569 Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. 2002 Sep 1
88 12433834 Phorbol ester induction of angiotensin-converting enzyme transcription is mediated by Egr-1 and AP-1 in human endothelial cells via ERK1/2 pathway. 2002 Nov 15 2
89 12489106 Mechanism of action of a dominant negative c-jun mutant in inhibiting activator protein-1 activation. 2002 Dec 1
90 11050091 Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways. 2001 Jan 19 1
91 11226521 Phorbol ester responsiveness of the glutathione S-transferase P1 gene promoter involves an inducible c-jun binding in human K562 leukemia cells. 2001 Mar 5
92 11278336 Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. 2001 Apr 13 1
93 11356008 c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE). 2001 Apr 21 3
94 11408617 Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. 2001 Jul 2
95 11461775 Physiological amounts of ascorbate potentiate phorbol ester-induced nuclear-binding of AP-1 transcription factor in cells of macrophagic lineage. 2001 Aug 1 4
96 11479211 Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. 2001 Aug 1 4
97 11502881 Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. 2001 Sep 1
98 11716547 The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation. 2001 Dec 10 1
99 11719466 Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. 2001 Nov 15 1
100 11749832 Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells. 2001 Jul 1