Pub. Date : 2004 Apr
PMID : 15047839
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Early activation of the Kaposi"s sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Cotransfected cJUN plus cFOS or TPA treatment transactivated the KSHV RTA, RAP, and MTA promoters in an AP1-binding site-dependent manner in all three promoters. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | Chromatin immunoprecipitation assays confirmed that cJUN associates with these KSHV target promoters in PEL cells as early as 4 h after TPA treatment. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 7 | Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 8 | Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 9 | Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 10 | Therefore, we suggest that the initiating effects of TPA via the AP1 pathway in PEL cells need to be amplified by RTA for full lytic-cycle induction. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |