| 1 |
34750506 | The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML. | 2022 Mar |
2 |
| 2 |
35311954 | Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML. | 2022 Jun 6 |
1 |
| 3 |
31217189 | PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia. | 2019 Aug 8 |
2 |
| 4 |
28271164 | Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. | 2017 Jul |
2 |
| 5 |
23127761 | Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases. | 2013 Mar |
1 |
| 6 |
22942183 | Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. | 2012 Oct 18 |
3 |
| 7 |
21768087 | c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. | 2011 Sep 2 |
1 |
| 8 |
19438505 | A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. | 2009 Jul |
1 |
| 9 |
16627759 | Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. | 2006 Aug 15 |
3 |
| 10 |
15345593 | Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). | 2005 Jan 1 |
2 |
| 11 |
16091740 | Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant. | 2005 Dec 8 |
5 |
| 12 |
11971190 | Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. | 2002 Apr 11 |
5 |
| 13 |
12145695 | Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors. | 2002 Aug |
1 |
| 14 |
12384447 | A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia. | 2002 Nov 1 |
1 |
| 15 |
11290608 | Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. | 2001 Apr 15 |
1 |
| 16 |
11587362 | FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy. | 2001 Aug |
1 |
| 17 |
10720129 | In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor. | 2000 Mar |
1 |
| 18 |
11021752 | Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. | 2000 Oct |
1 |
| 19 |
9918857 | p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells. | 1999 Jan 19 |
1 |
| 20 |
10080542 | Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. | 1999 Mar |
1 |
| 21 |
10482988 | SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor. | 1999 Sep |
4 |