Title : Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML.

Pub. Date : 2022 Jun 6

PMID : 35311954






1 Functional Relationships(s)
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1 Mechanistically, SHP2 inhibition induced tyrosine phosphorylation and feedback-driven activation of the FLT3 receptor, which in turn phosphorylated SHP2 on tyrosine 62. Tyrosine FMS-like tyrosine kinase 3 Mus musculus