Pub. Date : 2011 May 15
PMID : 21372224
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. | Irinotecan | tumor associated calcium signal transducer 2 | Homo sapiens |
| 2 | PURPOSE: Evaluate the efficacy of an SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, and to assess its tolerability in mice and monkeys, the latter with tissue cross-reactivity to hRS7 similar to humans. | Irinotecan | tumor associated calcium signal transducer 2 | Homo sapiens |
| 3 | EXPERIMENTAL DESIGN: Two SN-38 derivatives, CL2-SN-38 and CL2A-SN-38, were conjugated to the anti-Trop-2-humanized antibody, hRS7. | Irinotecan | tumor associated calcium signal transducer 2 | Homo sapiens |
| 4 | CONCLUSIONS: The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types. | Irinotecan | tumor associated calcium signal transducer 2 | Homo sapiens |