Cotinine

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cytochrome P450 family 2 subfamily A member 6 ; Homo sapiens







82 Article(s)
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Title
Pub. Year
#Total Relationships
51 17220563 In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. 2006 Dec 3
52 15940289 Association of CYP2A6*1B genetic variant with the amount of smoking in French adults from the Stanislas cohort. 2005 1
53 15998359 Porcine CYP2A polymorphisms and activity. 2005 Aug 2
54 16141602 Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation. 2005 Aug 3
55 16272956 CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. 2005 Dec 1
56 16359169 Identification of N-(hydroxymethyl) norcotinine as a major product of cytochrome P450 2A6, but not cytochrome P450 2A13-catalyzed cotinine metabolism. 2005 Dec 1
57 16372023 Ethnic differences in nicotine metabolic rate among New Zealanders. 2005 Dec 16 1
58 15225612 Novel human CYP2A6 alleles confound gene deletion analysis. 2004 Jul 2 1
59 15265511 Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted. 2004 Aug 3
60 15592323 A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo. 2004 Dec 3
61 12488541 Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. 2003 Jan 1
62 12504349 Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. 2003 Feb 1 1
63 12844137 Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro. 2003 Jul 7
64 14577978 Nicotine metabolite ratio as a predictor of cigarette consumption. 2003 Oct 3
65 11805739 Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. 2002 Feb 1
66 12024803 Effects of whole deletion of CYP2A6 on nicotine metabolism in humans. 2002 May 2
67 12406643 CYP2A6 genetic variation and potential consequences. 2002 Nov 18 1
68 12487152 Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6. 2002 Nov 1
69 11180041 Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans. 2001 Jan 12
70 11259349 Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. 2001 Apr 1
71 11353760 Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. 2001 Jun 1
72 11401907 Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes. 2001 Jun 4
73 11434509 Nicotine metabolism and CYP2A6 allele frequencies in Koreans. 2001 Jun 3
74 10668854 Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans. 2000 Jan 2
75 10781881 CYP2A6: a human coumarin 7-hydroxylase. 2000 Apr 3 1
76 10999944 Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. 2000 Oct 1
77 10448083 The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP. 1999 Aug 19 1
78 10565842 Ethnic differences in N-glucuronidation of nicotine and cotinine. 1999 Dec 1
79 9316878 A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. 1997 Sep 4
80 8627511 Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes. 1996 May 3
81 8937855 Role of human cytochrome P4502A6 in C-oxidation of nicotine. 1996 Nov 6
82 7646564 In vitro-in vivo correlations of human (S)-nicotine metabolism. 1995 Aug 8 1