Pub. Date : 1996 Nov
PMID : 8937855
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cotinine formation in human liver microsomes significantly correlated with immunochemically determined CYP2A6 levels (r = 0.663, p < 0.05), coumarin 7-hydroxylase activities (r = 0.831, p < 0.01), and cotinine 3"-hydroxylase activities (r = 0.735, p < 0.01) that are responsible for CYP2A6. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | Cotinine formation in human liver microsomes significantly correlated with immunochemically determined CYP2A6 levels (r = 0.663, p < 0.05), coumarin 7-hydroxylase activities (r = 0.831, p < 0.01), and cotinine 3"-hydroxylase activities (r = 0.735, p < 0.01) that are responsible for CYP2A6. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | Cotinine formation in human liver microsomes significantly correlated with immunochemically determined CYP2A6 levels (r = 0.663, p < 0.05), coumarin 7-hydroxylase activities (r = 0.831, p < 0.01), and cotinine 3"-hydroxylase activities (r = 0.735, p < 0.01) that are responsible for CYP2A6. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | When the capability of microsomes of B-lymphoblastoid cells expressing human CYPs to perform biotransformation of nicotine to cotinine was determined, cDNA-expressed CYP2A6 exhibited the highest cotinine formation. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 5 | When the capability of microsomes of B-lymphoblastoid cells expressing human CYPs to perform biotransformation of nicotine to cotinine was determined, cDNA-expressed CYP2A6 exhibited the highest cotinine formation. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 6 | The large interindividual variabilities in cotinine formation and immunochemically determined CYP2A6 levels were observed in human liver microsomes, suggesting genetic polymorphism of CYP2A6. | Cotinine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |