threonyl-tRNA synthetase 1 ; Homo sapiens






25 Article(s)
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1 1701663 The relation between catalytic activity and gene regulation in the case of E coli threonyl-tRNA synthetase. Biochimie 1990 Jun-Jul 2
2 2747635 Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines. Mol Cell Biol 1989 May 1
3 10369889 Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease. Neurogenetics 1999 Apr 1
4 10881191 Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase. Nat Struct Biol 2000 Jun 1
5 11136973 Transfer RNA-mediated editing in threonyl-tRNA synthetase. The class II solution to the double discrimination problem. Cell 2000 Dec 8 1
6 15525511 Achieving error-free translation; the mechanism of proofreading of threonyl-tRNA synthetase at atomic resolution. Mol Cell 2004 Nov 5 6
7 17185419 Mechanism of tRNA-dependent editing in translational quality control. Proc Natl Acad Sci U S A 2007 Jan 2 2
8 19292486 Binding and enantiomeric selectivity of threonyl-tRNA synthetase. J Am Chem Soc 2009 Mar 25 2
9 21678129 Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs 2012 Aug 5
10 22482363 Molecular dynamics investigation into substrate binding and identity of the catalytic base in the mechanism of Threonyl-tRNA synthetase. J Phys Chem B 2012 May 3 2
11 23425968 Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. Sci Rep 2013 3
12 25489076 Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo. Proc Natl Acad Sci U S A 2014 Dec 23 2
13 25824639 Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun 2015 Mar 31 5
14 26617965 Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis. ACS Med Chem Lett 2015 Nov 12 1
15 28592109 Roles of the Active Site Zn(II) and Residues in Substrate Discrimination by Threonyl-tRNA Synthetase: An MD and QM/MM Investigation. J Phys Chem B 2017 Jun 29 13
16 29281289 Unraveling the Critical Role Played by <sub>Ado76</sub>2'OH in the Post-Transfer Editing by Archaeal Threonyl-tRNA Synthetase. J Phys Chem B 2018 Jan 25 6
17 29328069 Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration. Exp Mol Med 2018 Jan 12 2
18 29671451 A transition state "trapped"? QM-cluster models of engineered threonyl-tRNA synthetase. Org Biomol Chem 2018 Jun 6 4
19 32253314 Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells. Proc Natl Acad Sci U S A 2020 Apr 21 1
20 33178197 Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production <i>via</i> an NF-κB Pathway. Front Immunol 2020 1
21 33340489 Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Mol Cell 2021 Jan 21 3
22 33599525 Infrared Spectroscopy for Online Measurement of Tars, Water, and Permanent Gases in Biomass Gasification. Appl Spectrosc 2021 Jun 1
23 34159625 Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer. J Gastroenterol Hepatol 2021 Nov 1
24 34508595 Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease. Hum Mol Genet 2022 Feb 21 2
25 35636339 Comparative QM/MM study on the inhibition mechanism of β-Hydroxynorvaline to Threonyl-tRNA synthetase. J Mol Graph Model 2022 Sep 1