Title : Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.

Pub. Date : 2015 Mar 31

PMID : 25824639






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). Polyketides threonyl-tRNA synthetase 1 Homo sapiens
2 The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). Polyketides threonyl-tRNA synthetase 1 Homo sapiens
3 The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). borrelidin threonyl-tRNA synthetase 1 Homo sapiens
4 The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). borrelidin threonyl-tRNA synthetase 1 Homo sapiens
5 Thus, borrelidin competes with all three aminoacylation substrates, providing a potent and redundant mechanism to inhibit ThrRS during protein synthesis. borrelidin threonyl-tRNA synthetase 1 Homo sapiens