adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 ; Rattus norvegicus






21 Article(s)
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1 17848569 The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem 2007 Nov 2 2
2 21151013 Globular and full-length adiponectin induce NO-dependent vasodilation in resistance arteries of Zucker lean but not Zucker diabetic fatty rats. Am J Hypertens 2011 Mar 2
3 21543456 The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. J Endocrinol 2011 Jul 8
4 21552570 Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis. PLoS One 2011 Apr 28 4
5 22933778 Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway. J Neurosci 2012 Aug 29 1
6 23497197 Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats. Cardiovasc Diabetol 2013 Mar 18 2
7 25099270 AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts. PLoS One 2014 1
8 25164368 Palmitate induces ER stress and autophagy in H9c2 cells: implications for apoptosis and adiponectin resistance. J Cell Physiol 2015 Mar 1
9 26759813 Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis. J Diabetes Res 2016 2
10 29406784 Resistance training recovers attenuated APPL1 expression and improves insulin-induced Akt signal activation in skeletal muscle of type 2 diabetic rats. Am J Physiol Endocrinol Metab 2018 Jun 1 2
11 29991592 A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. J Biol Chem 2018 Aug 31 2
12 30684496 Alpha lipoic acid protects against dexamethasone-induced metabolic abnormalities via APPL1 and PGC-1 α up regulation. Steroids 2019 Apr 5
13 31530215 mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats. Mol Pain 2019 Jan-Dec 1
14 33571963 Nanomolar melatonin influences insulin synthesis and secretion in rat insulinoma INS-1E cells. J Physiol Pharmacol 2020 Oct 1
15 34304702 PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway. Bioengineered 2021 Dec 2
16 34396435 Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1. Mol Med Rep 2021 Oct 7
17 34919285 LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway. FASEB J 2022 Jan 5
18 34973346 Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats. Exp Gerontol 2022 Mar 1
19 35069838 APPL1 ameliorates myocardial ischemia-reperfusion injury by regulating the AMPK signaling pathway. Exp Ther Med 2022 Feb 5
20 35240124 Exercise ameliorates high-fat diet-induced insulin resistance accompanied by changes in protein levels of hepatic ATF3-related signaling in rats. Physiol Behav 2022 May 15 2
21 35509834 DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway. Oxid Med Cell Longev 2022 2