potassium inwardly rectifying channel subfamily J member 5 ; Homo sapiens






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1 7499400 The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. J Biol Chem 1995 Dec 1 2
2 8834003 Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel. Recept Channels 1995 1
3 9038938 ATP-dependent regulation of a G protein-coupled K+ channel (GIRK1/GIRK4) expressed in oocytes. Am J Physiol 1997 Jan 6
4 9478984 Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J Biol Chem 1998 Feb 27 1
5 10559906 Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nat Cell Biol 1999 Jul 11
6 10593888 Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem 1999 Dec 17 10
7 10889209 Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. J Biol Chem 2000 Sep 29 3
8 10956662 Residues and mechanisms for slow activation and Ba2+ block of the cardiac muscarinic K+ channel, Kir3.1/Kir3.4. J Biol Chem 2000 Nov 17 1
9 11278615 Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site. J Biol Chem 2001 May 4 2
10 11714649 Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials. Circulation 2001 Nov 20 2
11 11741896 Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. J Biol Chem 2002 Feb 22 5
12 12501240 Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis. J Biol Chem 2003 Feb 28 8
13 14504281 Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. J Biol Chem 2003 Dec 5 2
14 14525972 The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel. J Biol Chem 2003 Dec 12 1
15 15454439 K+ activation of kir3.1/kir3.4 and kv1.4 K+ channels is regulated by extracellular charges. Biophys J 2004 Oct 2
16 15980413 Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. J Biol Chem 2005 Sep 2 1
17 16109731 A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels. J Physiol 2005 Nov 1 6
18 17296805 Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol 2007 Apr 1
19 17967416 Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit. Biochem Biophys Res Commun 2007 Dec 28 1
20 18087715 Molecular basis for genistein-induced inhibition of Kir2.3 currents. Pflugers Arch 2008 May 3
21 18690021 Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels. Channels (Austin) 2007 Mar-Apr 1
22 18690025 Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix. Channels (Austin) 2007 May-Jun 6
23 18998087 Determination of phosphoinositide binding to K(+) channel subunits using a protein-lipid overlay assay. Methods Mol Biol 2008 1
24 19208499 The single nucleotide polymorphisms of Kir3.4 gene and their correlation with lone paroxysmal atrial fibrillation in Chinese Han population. Heart Lung Circ 2009 Aug 1
25 19252135 Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes 2009 Jun 1
26 19923917 Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop. Channels (Austin) 2010 Jan-Feb 4
27 20657029 Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol 2010 Oct 1
28 22278422 Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas. J Clin Endocrinol Metab 2012 Apr 1
29 22308486 Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci U S A 2012 Feb 14 1
30 22315453 Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology 2012 Apr 11
31 22331379 Visinin-like 1 is upregulated in aldosterone-producing adenomas with KCNJ5 mutations and protects from calcium-induced apoptosis. Hypertension 2012 Apr 5
32 22447138 Polyuric-polydipsic syndrome in a pediatric case of non-glucocorticoid remediable familial hyperaldosteronism. Endocr J 2012 1
33 22628607 A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. J Clin Endocrinol Metab 2012 Aug 4
34 22628608 Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab 2012 Aug 3
35 22798349 The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. Endocrinology 2012 Sep 6
36 22848660 Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS One 2012 3
37 23012392 Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling. J Clin Endocrinol Metab 2012 Dec 2
38 23229280 Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat Rev Endocrinol 2013 Feb 1
39 23305758 Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase. Biochim Biophys Acta 2013 Apr 5
40 23376008 KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling. Mol Cell Endocrinol 2013 May 22 2
41 23426162 Primary aldosteronism and potassium channel mutations. Curr Opin Endocrinol Diabetes Obes 2013 Jun 2
42 23610123 Genetics of mineralocorticoid excess: an update for clinicians. Eur J Endocrinol 2013 Jul 1
43 23829355 Regulation of aldosterone biosynthesis by the Kir3.4 (KCNJ5) potassium channel. Clin Exp Pharmacol Physiol 2013 Dec 4
44 23913004 Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 2013 Sep 1
45 23943609 A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels. Sci Signal 2013 Aug 13 2
46 23946277 Lack of influence of somatic mutations on steroid gradients during adrenal vein sampling in aldosterone-producing adenoma patients. Eur J Endocrinol 2013 Nov 1
47 24037882 a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. J Clin Endocrinol Metab 2013 Nov 4
48 24179102 Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. Endocr Relat Cancer 2014 Feb 1
49 24248457 Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy? Endocrinology 2014 Jan 3
50 24506072 Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas. Endocrinology 2014 Apr 3