Title : Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling.

Pub. Date : 2012 Dec

PMID : 23012392






2 Functional Relationships(s)
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1 CONTEXT: Somatic mutations in the selectivity filter of KCNJ5 K(+) channel were found to be associated with higher plasma aldosterone concentrations in the patients with an aldosterone-producing adenoma (APA). Aldosterone potassium inwardly rectifying channel subfamily J member 5 Homo sapiens
2 CONCLUSIONS: APA patients with the somatic KCNJ5 mutations showed a higher production of aldosterone than those without such mutations, which translates in a higher lateralization index. Aldosterone potassium inwardly rectifying channel subfamily J member 5 Homo sapiens