methyl-CpG binding protein 2 ; Homo sapiens






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1 8001979 Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome. Genomics 1994 Aug 1
2 9038338 MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 1997 Feb 21 1
3 9271441 Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2. Mol Cell Biol 1997 Sep 1
4 9916800 Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999 Jan 2
5 10390525 Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2). Nucleic Acids Res 1999 Jul 15 2
6 10508514 Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999 Oct 1
7 11262731 Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations. Curr Opin Neurol 2001 Apr 1
8 11331619 MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome. Hum Mol Genet 2001 May 1 1
9 11392517 Occurrence of Rett syndrome in boys. J Child Neurol 2001 May 1
10 11453972 Rett syndrome from quintuple and triple deletions within the MECP2 deletion hotspot region. Clin Genet 2001 Jun 4
11 11861904 Methylation-dependent silencing at the H19 imprinting control region by MeCP2. Nucleic Acids Res 2002 Mar 1 1
12 11865062 Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol 2002 Mar 1
13 12107440 MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. Hum Genet 2002 Jun 1
14 12112735 Associations between MeCP2 mutations, X-chromosome inactivation, and phenotype. Ment Retard Dev Disabil Res Rev 2002 2
15 12427740 The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 2003 Feb 7 3
16 14598336 MECP2 gene mutations in non-syndromic X-linked mental retardation: phenotype-genotype correlation. Am J Med Genet A 2003 Dec 1 2
17 14974082 Large deletions of the MECP2 gene detected by gene dosage analysis in patients with Rett syndrome. Hum Mutat 2004 Mar 1
18 15247904 Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer. Oncogene 2004 Aug 26 1
19 15322089 MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. J Biol Chem 2004 Nov 5 1
20 15549394 The impact of MECP2 mutations in the expression patterns of Rett syndrome patients. Hum Genet 2005 Jan 1
21 15591025 DNA methylation affects cell proliferation, cortisol secretion and steroidogenic gene expression in human adrenocortical NCI-H295R cells. J Mol Endocrinol 2004 Dec 1
22 15689352 Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet 2005 Mar 15 1
23 15809347 The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. J Biochem 2005 Mar 1
24 15917437 5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2). Nucleic Acids Res 2005 4
25 15959553 MeCP2: the chromatin connection and beyond. Biochem Cell Biol 2005 Jun 2
26 16647848 MeCP2 dysfunction in Rett syndrome and related disorders. Curr Opin Genet Dev 2006 Jun 1
27 16786000 CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2. Oncogene 2006 Aug 3 2
28 17036333 SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein. Int J Cancer 2006 Dec 15 1
29 17046689 Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 2006 Oct 19 2
30 17084570 Low significance of MECP2 mutations as a cause of mental retardation in Brazilian males. Brain Dev 2007 Jun 1
31 17171659 Sequence variants within exon 1 of MECP2 occur in females with mental retardation. Am J Med Genet B Neuropsychiatr Genet 2007 Apr 5 2
32 17339270 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet 2007 Mar 15 1
33 17363207 Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome. Brain Dev 2007 Sep 2
34 17371874 Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. J Biol Chem 2007 May 18 3
35 17698632 Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 2007 Nov 15 2
36 18204074 Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells. Carcinogenesis 2008 Jun 1
37 18302774 Characterization of novel isoforms and evaluation of SNF2L/SMARCA1 as a candidate gene for X-linked mental retardation in 12 families linked to Xq25-26. BMC Med Genet 2008 Feb 26 1
38 18310117 Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. J Exp Biol 2008 Mar 6
39 18477000 Severe congenital encephalopathy caused by MECP2 null mutations in males: central hypoxia and reduced neuronal dendritic structure. Clin Genet 2008 Aug 1
40 18492797 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol 2008 Aug 1
41 18513492 ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9. Biochim Biophys Acta 2008 Oct 1
42 18550052 Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. Eur J Pharmacol 2008 Jul 28 3
43 18723031 Comparison of global DNA methylation profiles in replicative versus premature senescence. Life Sci 2008 Sep 26 1
44 18773074 Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet 2008 Sep 5 1
45 18952054 Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation. Biochem Biophys Res Commun 2008 Dec 19 2
46 19012748 Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation. J Neurochem 2009 Jan 2
47 19034540 The first missense mutation causing Rett syndrome specifically affecting the MeCP2_e1 isoform. Neurogenetics 2009 Apr 1
48 19109157 Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009 Jan 1 1
49 19116135 Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells. Biochem Biophys Res Commun 2009 Feb 6 1
50 19120127 Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder. Ann N Y Acad Sci 2008 Dec 1