Title : Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

Pub. Date : 2009 Jan 1

PMID : 19109157






1 Functional Relationships(s)
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1 We identified a unique and evolutionarily conserved CpG-rich island of the Foxp3 nonintronic upstream enhancer and discovered that a specific site within it was unmethylated in natural Treg (nTreg) but heavily methylated in naive CD4(+) T cells, activated CD4(+) T cells, and peripheral TGFbeta-induced Treg in which it was bound by DNMT1, DNMT3b, MeCP2, and MBD2. treg methyl-CpG binding protein 2 Homo sapiens