SMAD family member 2 ; Rattus norvegicus






305 Article(s)
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51 19659652 Simvastatin attenuates experimental small airway remodelling in rats. Respirology 2009 Jul 1
52 19808328 Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy. Circ Heart Fail 2009 Mar 1
53 19834880 Increased expression of phosphorylated Smad2 and Smad3 in the hippocampus of streptozotocin-induced diabetic rats. Exp Clin Endocrinol Diabetes 2010 Jan 4
54 19861282 [Smad7 inhibits collagen expression in human hepatic satellite cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao 2009 Oct 1
55 19941153 Early administration of propofol protects against endotoxin-induced acute lung injury in rats by inhibiting the TGF-beta1-Smad2 dependent pathway. Inflamm Res 2010 Jul 3
56 20047646 The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair 2010 Jan 4 2
57 20127712 Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling. J Cell Biochem 2010 Apr 15 1
58 20142807 Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-beta/Smad activity. Lab Invest 2010 Mar 1
59 20154262 Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol 2010 May 1
60 20226149 [Effects of Shenqi Jiedu Decoction on expressions of transforming growth factor-beta1, smad2 and smad3 in renal tissues of rats with chronic renal failure induced by adenine]. Zhong Xi Yi Jie He Xue Bao 2010 Mar 1
61 20466671 Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells. Nephrol Dial Transplant 2010 Oct 4
62 20496196 Effects of bicyclol on immunological liver fibrosis in rats. J Asian Nat Prod Res 2010 May 1
63 20818498 Role of cross-talk between the Smad2 and MAPK pathways in TGF-beta1-induced collagen IV expression in mesangial cells. Int J Mol Med 2010 Oct 3
64 20849043 Levosimendan up-regulates transforming growth factor-beta and smad signaling in the aorta in the early stage of sepsis. Ulus Travma Acil Cerrahi Derg 2010 Jul 1
65 20980683 Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA). Biol Reprod 2011 Feb 3
66 21144460 [Effects of Chinese herbal medicine Yiqi Huoxue Formula on TGF-β/smad signal transduction pathway and connective tissue growth factor in rats with renal interstitial fibrosis]. Zhong Xi Yi Jie He Xue Bao 2010 Dec 1
67 21265825 Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro. Br J Pharmacol 2011 Jun 1
68 21300041 Resveratrol ameliorates early diabetic nephropathy associated with suppression of augmented TGF-β/smad and ERK1/2 signaling in streptozotocin-induced diabetic rats. Chem Biol Interact 2011 Mar 15 1
69 21337027 Effects of amlodipine on TGF-β-induced Smad2, 4 expressions in adriamycin toxicity of rat mesangial cells. Arch Toxicol 2011 Jun 5
70 21367774 Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. Cardiovasc Res 2011 Jul 1 1
71 21420391 MG132 treatment attenuates cardiac remodeling and dysfunction following aortic banding in rats via the NF-κB/TGFβ1 pathway. Biochem Pharmacol 2011 May 15 1
72 21457293 Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts. Clin Exp Pharmacol Physiol 2011 Jun 1
73 21497498 Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. J Nutr Biochem 2012 Mar 1
74 21605584 Inhibition of arsenic-induced rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation. Toxicol Appl Pharmacol 2011 Aug 1 1
75 21605637 In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose. Fitoterapia 2011 Sep 1
76 21779727 [The effect of different concentrations of fluoride on the expression of Smad2/3 in ameloblast of rat incisor]. Shanghai Kou Qiang Yi Xue 2011 Jun 3
77 21897055 Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts. J Pharmacol Sci 2011 4
78 21925118 Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells. Transl Res 2011 Oct 2
79 21967314 Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats. J Sex Med 2011 Oct 1
80 21984124 Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192. J Pathol 2011 Nov 1
81 22032678 Oral application of 1,7-dimethylxanthine (paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis. Hepatol Res 2011 Nov 1
82 22035631 Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-β/Smad signaling pathway. Thromb Res 2012 Apr 1
83 22381758 [Effect of atorvastatin on cardiac function and TGF-β1 signaling pathway after acute myocardial infarction in rats]. Nan Fang Yi Ke Da Xue Xue Bao 2012 Feb 2
84 22619697 Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model. Oxid Med Cell Longev 2012 1
85 22679731 [Garlicin ameliorated pressure overload induced myocardial fibrosis in rats through partial inhibiting TGF-beta1 mediated Smads signal]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2012 May 2
86 22745681 Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism. PLoS One 2012 1
87 22922645 RhoA/Rho kinase signaling regulates transforming growth factor-β1-induced chondrogenesis and actin organization of synovium-derived mesenchymal stem cells through interaction with the Smad pathway. Int J Mol Med 2012 Nov 2
88 22964151 [Effect of TGF-b1 siRNA-mediated silencing on Smad proteins in hepatic fibrosis rats]. Zhonghua Gan Zang Bing Za Zhi 2012 Apr 1
89 22978413 Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med 2012 Sep 16 2
90 22989552 Two drugs with paradoxical effects on liver regeneration through antiangiogenesis and antifibrosis: Losartan and Spironolactone: a pharmacologic dilemma on hepatocyte proliferation. J Surg Res 2013 Jan 3
91 23019951 [Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2012 Jul 1
92 23142711 Proteasome inhibition attenuates heart failure during the late stages of pressure overload through alterations in collagen expression. Biochem Pharmacol 2013 Jan 15 1
93 23258196 Rosuvastatin attenuates inflammation, apoptosis and fibrosis in a rat model of cyclosporine-induced nephropathy. Am J Nephrol 2013 1
94 23477149 [Regulatory effect of berberine on unbalanced expressions of renal tissue TGF-beta1/SnoN and smad signaling pathway in rats with early diabetic nephropathy]. Zhongguo Zhong Yao Za Zhi 2012 Dec 1
95 23665496 Pentamethylquercetin ameliorates fibrosis in diabetic Goto-Kakizaki rat kidneys and mesangial cells with suppression of TGF-β/Smads signaling. Eur J Pharmacol 2013 Aug 5 1
96 23772748 Icariin attenuates high glucose-induced type IV collagen and fibronectin accumulation in glomerular mesangial cells by inhibiting transforming growth factor-β production and signalling through G protein-coupled oestrogen receptor 1. Clin Exp Pharmacol Physiol 2013 Sep 1
97 23830891 Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3. Int J Biochem Cell Biol 2013 Sep 3
98 23959527 Smad7 modulates TGFβ signaling during cranial suture development to maintain suture patency. J Bone Miner Res 2014 Mar 2
99 24041947 Transforming growth factor-β regulates endothelial function during high salt intake in rats. Hypertension 2013 Nov 2
100 24211420 Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol Lett 2014 Jan 13 1