| Protein Name | SMAD family member 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29357 |
| Gene Symbol | Smad2 |
| UniProt | O70436 (SMAD2_RAT), A0A0G2K0P2 (A0A0G2K0P2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
248
Total Number of Articles : 305 |
Description |
SMAD family member 2 |
| Gene Summary |
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to glucose stimulus; and regulation of gene expression. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). [provided by Alliance of Genome Resources, Jul 2025] |
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