thymidine kinase 2 ; Homo sapiens






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1 605384 Human mitochondrial thymidine kinase is coded for by a gene on chromosome 16 of the nucleus. Somatic Cell Genet 1977 May 2
2 1359886 Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. Biochem Biophys Res Commun 1992 Oct 30 2
3 1433372 Can thymidine kinase levels in breast tumors predict disease recurrence? J Natl Cancer Inst 1992 Dec 2 8
4 1597187 Mammalian thymidine kinase 2. Direct photoaffinity labeling with [32P]dTTP of the enzyme from spleen, liver, heart and brain. Eur J Biochem 1992 Jun 1 6
5 1597439 Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways. J Biol Chem 1992 Jun 5 4
6 1657002 Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity. Biochem Pharmacol 1991 Oct 9 2
7 2025274 Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs. Biochem Biophys Res Commun 1991 Apr 30 4
8 2026611 Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides. J Biol Chem 1991 May 15 11
9 6504022 Differences in the kinetic properties of thymidine kinase isoenzymes in unstimulated and phytohemagglutinin-stimulated human lymphocytes. Mol Cell Biochem 1984 Sep 9
10 7572355 Human thymidine kinase 1. Regulation in normal and malignant cells. Adv Enzyme Regul 1995 2
11 7637389 Increased ratio between deoxycytidine kinase and thymidine kinase 2 in CLL lymphocytes compared to normal lymphocytes. Leuk Res 1995 Jul 5
12 8358097 Occupational dermatitis from isothiazolinones in the nylon production. Dermatology 1993 2
13 8726039 Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity. Antimicrob Agents Chemother 1996 Jun 2
14 9079672 Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2. J Biol Chem 1997 Mar 28 7
15 9359870 Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues. Biochem J 1997 Nov 15 15
16 9461577 Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase. J Biol Chem 1998 Feb 13 4
17 9598103 Deoxycytidine kinase can be also potentiated by the G-protein activator NaF in cells. Adv Exp Med Biol 1998 1
18 9598140 Substrate/inhibitor specificities of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2). Adv Exp Med Biol 1998 2
19 9598147 Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC). Adv Exp Med Biol 1998 2
20 9989599 Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates. FEBS Lett 1999 Jan 25 3
21 10432682 The enantioselectivity of the cellular deoxynucleoside kinases. Nucleosides Nucleotides 1999 Apr-May 1
22 10464024 Synthesis of 5-(carboranylalkylmercapto)-2'-deoxyuridines and 3-(carboranylalkyl)thymidines and their evaluation as substrates for human thymidine kinases 1 and 2. J Med Chem 1999 Aug 26 1
23 10478487 Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues. Nucleosides Nucleotides 1999 Aug 10
24 10606535 Stereoisomeric selectivity of human deoxyribonucleoside kinases. Biochemistry 1999 Dec 21 5
25 10799656 Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth. Biochem Pharmacol 2000 Jun 15 8
26 10998359 Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2. Biochem J 2000 Oct 1 2
27 11266658 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase. Biochem Pharmacol 2001 Mar 15 11
28 11687800 The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. Nat Genet 2001 Nov 4
29 11687801 Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet 2001 Nov 4
30 11708900 Zidovudine phosphorylation and mitochondrial toxicity in vitro. Toxicol Appl Pharmacol 2001 Nov 15 1
31 11929696 Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines. Nucl Med Biol 2002 Apr 1
32 12123744 3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells. Biochem Pharmacol 2002 Jul 15 3
33 12127539 Synthesis and biological evaluation of 3'-carboranyl thymidine analogues. Bioorg Med Chem Lett 2002 Aug 19 2
34 12213066 Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem 2002 Sep 12 3
35 12391347 Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA. Neurology 2002 Oct 22 4
36 12493767 Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy. J Biol Chem 2003 Feb 28 4
37 12527796 Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase. Mol Pharmacol 2003 Feb 4
38 12873860 Mitochondrial myopathy of childhood associated with mitochondrial DNA depletion and a homozygous mutation (T77M) in the TK2 gene. Arch Neurol 2003 Jul 2
39 14659972 2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells. Life Sci 2004 Jan 2 1
40 14690426 Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms. Biochemistry 2003 Dec 30 14
41 15336255 Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties. Bioorg Med Chem 2004 Sep 15 1
42 15351391 Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes. Bioorg Med Chem 2004 Oct 1 4
43 15571232 Deoxyribonucleoside kinases in mitochondrial DNA depletion. Nucleosides Nucleotides Nucleic Acids 2004 Oct 2
44 15628745 Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases. Nucleosides Nucleotides Nucleic Acids 2004 1
45 15634740 A computational model of mitochondrial deoxynucleotide metabolism and DNA replication. Am J Physiol Cell Physiol 2005 May 1
46 15779915 Kinetic analysis and ligand-induced conformational changes in dimeric and tetrameric forms of human thymidine kinase 2. Biochemistry 2005 Mar 29 10
47 15921863 Disorders of nuclear-mitochondrial intergenomic signaling. Gene 2005 Jul 18 4
48 16305527 Mitochondrial thymidine kinase inhibitors. Curr Top Med Chem 2005 10
49 16630572 Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts. Biochem Biophys Res Commun 2006 May 26 3
50 16908738 Clinical spectrum of mitochondrial DNA depletion due to mutations in the thymidine kinase 2 gene. Arch Neurol 2006 Aug 2