Pub. Date : 2000 Jun 15
PMID : 10799656
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitochondrial thymidine kinase (TK2) phosphorylates pyrimidine nucleosides to monophosphates and is expressed constitutively through the cell cycle in all cells. | Pyrimidine Nucleosides | thymidine kinase 2 | Homo sapiens |
| 2 | Mitochondrial thymidine kinase (TK2) phosphorylates pyrimidine nucleosides to monophosphates and is expressed constitutively through the cell cycle in all cells. | monophosphates | thymidine kinase 2 | Homo sapiens |
| 3 | Because of the overlap of its substrate specificity with that of the cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK), it has been difficult to determine the role of TK2 in activating nucleosides used in chemotherapy. | Nucleosides | thymidine kinase 2 | Homo sapiens |
| 4 | In this report, we described the construction of a recombinant Escherichia coli strain which could be used to test if TK2 activity is limiting for the toxicity of nucleosides. | Nucleosides | thymidine kinase 2 | Homo sapiens |
| 5 | Enzymes of bacterial origin which are involved in thymidine and deoxyuridine anabolism and catabolism were eliminated, and the cDNA for human TK2 was introduced. | Thymidine | thymidine kinase 2 | Homo sapiens |
| 6 | Enzymes of bacterial origin which are involved in thymidine and deoxyuridine anabolism and catabolism were eliminated, and the cDNA for human TK2 was introduced. | Deoxyuridine | thymidine kinase 2 | Homo sapiens |
| 7 | These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides. | Pyrimidine Nucleosides | thymidine kinase 2 | Homo sapiens |
| 8 | These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides. | Nucleosides | thymidine kinase 2 | Homo sapiens |