Title : Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways.

Pub. Date : 1992 Jun 5

PMID : 1597439






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The substrate specificity of TK in macrophages strongly suggests that mitochondrial TK2 was the enzyme phosphorylating thymidine and AZT in these cells, whereas it was cytosolic TK1 in stimulated lymphocytes. Thymidine thymidine kinase 2 Homo sapiens
2 The substrate specificity of TK in macrophages strongly suggests that mitochondrial TK2 was the enzyme phosphorylating thymidine and AZT in these cells, whereas it was cytosolic TK1 in stimulated lymphocytes. Zidovudine thymidine kinase 2 Homo sapiens
3 The lack of catabolism together with phosphorylation by TK2 clarifies how AZT can inhibit human immunodeficiency virus in macrophages. Zidovudine thymidine kinase 2 Homo sapiens
4 The fact that TK2 and not TK1 phosphorylates AZT in macrophages should have important implications for combination chemotherapy. Zidovudine thymidine kinase 2 Homo sapiens