UMI-77






10 Article(s)
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1 24019208 A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther 2014 Mar 3
2 25749177 Targeting mcl-1 for radiosensitization of pancreatic cancers. Transl Oncol 2015 Feb 4
3 28337703 UMI-77 primes glioma cells for TRAIL-induced apoptosis by unsequestering Bim and Bak from Mcl-1. Mol Cell Biochem 2017 Aug 13
4 28659182 Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. BMC Cancer 2017 Jun 28 5
5 30479840 Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell Death Discov 2018 1
6 30796196 Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death Dis 2019 Feb 22 2
7 32737157 Targeting the Synthetic Vulnerability of <i>PTEN</i>-Deficient Glioblastoma Cells with MCL1 Inhibitors. Mol Cancer Ther 2020 Oct 1
8 33184293 Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. Nat Commun 2020 Nov 12 2
9 33342330 Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease. Autophagy 2021 Mar 3
10 35524750 Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis. FASEB J 2022 Jun 2