Title : A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo.

Pub. Date : 2014 Mar

PMID : 24019208






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 UMI-77 binds to the BH3-binding groove of Mcl-1 with Ki of 490 nmol/L, showing selectivity over other members of the antiapoptotic Bcl-2 family. UMI-77 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 UMI-77 inhibits cell growth and induces apoptosis in pancreatic cancer cells in a time- and dose-dependent manner, accompanied by cytochrome c release and caspase-3 activation. UMI-77 cytochrome c, somatic Homo sapiens
3 UMI-77 inhibits cell growth and induces apoptosis in pancreatic cancer cells in a time- and dose-dependent manner, accompanied by cytochrome c release and caspase-3 activation. UMI-77 caspase 3 Homo sapiens