Pub. Date : 2015 Feb
PMID : 25749177
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We next tested the ability of the recently identified, selective, small molecule inhibitor of Mcl-1, UMI77, to radiosensitize in pancreatic cancer cells. | UMI-77 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | UMI77 caused dissociation of Mcl-1 from the pro-apoptotic protein Bak and produced significant radiosensitization in BxPC-3 and Panc-1 cells, but minimal radiosensitization in MiaPaCa-2 cells. | UMI-77 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | UMI77 caused dissociation of Mcl-1 from the pro-apoptotic protein Bak and produced significant radiosensitization in BxPC-3 and Panc-1 cells, but minimal radiosensitization in MiaPaCa-2 cells. | UMI-77 | BCL2 antagonist/killer 1 | Homo sapiens |
| 4 | Radiosensitization by UMI77 was associated with Caspase-3 activation and PARP cleavage. | UMI-77 | collagen type XI alpha 2 chain | Homo sapiens |