6-methyl-2-(phenylethynyl)pyridine






319 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 10530811 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 1999 Oct 1
2 10934211 The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. J Biol Chem 2000 Oct 27 4
3 11040347 Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats. Eur J Pharmacol 2000 Oct 20 2
4 11082464 Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents. J Pharmacol Exp Ther 2000 Dec 1
5 11090117 Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 2000 Dec 3
6 11123360 mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 2001 Jan 2
7 11292452 The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain Res 2001 Apr 13 4
8 11387395 Group I mGluRs coupled to G proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain. J Neurophysiol 2001 Jun 1
9 11445180 The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats. Neuropharmacology 2001 Jul 2
10 11543761 Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. Neuropharmacology 2001 Sep 2
11 11591458 Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience 2001 1
12 11743947 Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain Res 2001 Dec 20 2
13 11880516 Signaling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network. J Neurosci 2002 Mar 1 3
14 11897107 Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons. Neuropharmacology 2002 Mar 2
15 11923431 Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. J Neurosci 2002 Apr 1 2
16 11973471 Induction mechanisms for L-LTP at thalamic input synapses to the lateral amygdala: requirement of mGluR5 activation. Neuroreport 2002 Apr 16 1
17 12010773 Interaction of group I mGlu and NMDA receptor agonists within the dorsal horn of the spinal cord of the juvenile rat. Br J Pharmacol 2002 May 2
18 12077217 The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J Neurosci 2002 Jun 15 2
19 12091536 Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism. J Neurophysiol 2002 Jul 2
20 12097497 Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 2002 Jul 1 5
21 12097518 Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism. J Neurosci 2002 Jul 1 4
22 12117582 Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacol Biochem Behav 2002 Sep 1
23 12117590 Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. Pharmacol Biochem Behav 2002 Sep 4
24 12117592 Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol Biochem Behav 2002 Sep 2
25 12117593 Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats. Pharmacol Biochem Behav 2002 Sep 1
26 12139116 Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia. Pol J Pharmacol 2002 Mar-Apr 2
27 12231639 Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei. J Physiol 2002 Sep 15 2
28 12354644 Metabotropic glutamate receptor involvement in phosphoinositide hydrolysis stimulation by an endogenous Na(+), K(+)-ATPase inhibitor and ouabain in neonatal rat brain. Brain Res Dev Brain Res 2002 Oct 20 1
29 12364493 Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol 2002 Oct 2
30 12373538 The role of striatal metabotropic glutamate receptors in degeneration of dopamine neurons: review article. Amino Acids 2002 2
31 12473093 Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur J Neurosci 2002 Dec 4
32 12494407 The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse 2003 Mar 3
33 12505681 mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation. Brain Res 2003 Jan 17 4
34 12527469 The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology 2002 Dec 1
35 12527470 Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 2002 Dec 2
36 12559117 Corticostriatal LTP requires combined mGluR1 and mGluR5 activation. Neuropharmacology 2003 Jan 3
37 12575822 Neuroprotective activity of metabotropic glutamate receptor ligands. Adv Exp Med Biol 2002 2
38 12660307 Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther 2003 Jul 1
39 12668042 Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems. Neuropharmacology 2003 Apr 3
40 12682710 The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl) 2003 May 2
41 12727324 The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats. Neurosci Lett 2003 May 15 2
42 12742254 MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Behav Brain Res 2003 May 15 1
43 12763091 Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat. Neuropharmacology 2003 Jun 1
44 12907309 Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. Neuropharmacology 2003 Sep 4
45 13679408 Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. J Neurophysiol 2004 Jan 1
46 14500738 Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Mol Pharmacol 2003 Oct 1
47 14519508 Long term potentiation varies with layer in rat visual cortex. Brain Res 2003 Oct 31 1
48 14552898 Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. Exp Neurol 2003 Oct 2
49 14726993 Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology (Berl) 2004 Jul 3
50 14735132 mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 2004 May 1