Pub. Date : 2002 Sep
PMID : 12117590
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 2 | The selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), 2-methyl-6-(phenylethynyl)pyridine (MPEP) was shown to display anxiolytic-like activity in a number of unconditioned assays of stress and anxiety (elevated plus maze, shock probe burying, marble burying, social interaction, and stress-induced hyperthermia) in rodents. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 3 | The selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), 2-methyl-6-(phenylethynyl)pyridine (MPEP) was shown to display anxiolytic-like activity in a number of unconditioned assays of stress and anxiety (elevated plus maze, shock probe burying, marble burying, social interaction, and stress-induced hyperthermia) in rodents. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 4 | Thus, these findings confirm and extend previous reports that MPEP exhibits anxiolytic-like activity in rats, and suggests that development of mGluR5 antagonists may provide a novel approach to treating anxiety disorders. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |