agomelatine






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1 12177586 Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int Clin Psychopharmacol 2002 Sep 1
2 12750432 The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 2003 Sep 2
3 15380370 Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain. Neuropharmacology 2004 Sep 1
4 16225556 Newer treatment studies for bipolar depression. Bipolar Disord 2005 1
5 16436935 Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system. Int Clin Psychopharmacol 2006 Feb 6
6 16687314 Therapeutic potential of melatonin ligands. Chronobiol Int 2006 2
7 16918076 Homology modelling of the serotoninergic 5-HT2c receptor. J Enzyme Inhib Med Chem 2006 Jun 1
8 17140278 Agomelatine: a preliminary review of a new antidepressant. CNS Drugs 2006 1
9 17477888 Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder. Int J Neuropsychopharmacol 2007 Oct 1
10 17917562 Evidence of agomelatine's antidepressant efficacy: the key points. Int Clin Psychopharmacol 2007 Oct 4
11 17917563 High-quality remission: potential benefits of the melatonergic approach for patients with major depressive disorder. Int Clin Psychopharmacol 2007 Oct 1
12 18583104 Agomelatine: a novel mechanism of antidepressant action involving the melatonergic and the serotonergic system. Eur Psychiatry 2008 Sep 3
13 18706130 The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats. Int J Neuropsychopharmacol 2009 Apr 2
14 19571795 Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology 2009 Oct 5
15 19758108 Agomelatine, a melatonin agonist with antidepressant properties. Expert Opin Investig Drugs 2009 Oct 2
16 19777735 [Agomelatine]. Med Monatsschr Pharm 2009 Aug 3
17 19827314 [Depression as chronobiological illness]. Neuropsychopharmacol Hung 2009 Jun 2
18 19966905 Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults. Neuropsychiatr Dis Treat 2009 1
19 20109111 Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration. World J Biol Psychiatry 2010 Mar 10
20 20236141 The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats. CNS Neurosci Ther 2010 Aug 2
21 20525261 Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways. BMC Neurosci 2010 Jun 3 1
22 20577266 Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov 2010 Aug 1
23 20685215 Effect of agomelatine and its interaction with the daily corticosterone rhythm on progenitor cell proliferation in the dentate gyrus of the adult rat. Neuropharmacology 2010 Nov 1
24 20874703 The emerging role of melatonin agonists in the treatment of major depression: focus on agomelatine. CNS Neurol Disord Drug Targets 2011 Feb 1
25 21181122 Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine. Psychopharmacology (Berl) 2011 May 4
26 21453740 Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1 4
27 21476953 Circadian rhythms, melatonin and depression. Curr Pharm Des 2011 1
28 21503609 Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats. Psychopharmacology (Berl) 2011 Oct 1
29 21688292 Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain. J Neurosci Res 2011 Oct 5
30 21830835 A benefit-risk assessment of agomelatine in the treatment of major depression. Drug Saf 2011 Sep 1 1
31 21916789 Agomelatine for the treatment of major depressive disorder. Expert Opin Pharmacother 2011 Oct 5
32 21925847 The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure. Eur Neuropsychopharmacol 2012 Mar 1
33 21999473 Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors. World J Biol Psychiatry 2011 Dec 4
34 22040921 Agomelatine suppresses locomotor hyperactivity in olfactory bulbectomised rats: a comparison to melatonin and to the 5-HT(2c) antagonist, S32006. Eur J Pharmacol 2012 Jan 5 1
35 22102540 The effects of agomelatine on sexual function in depressed patients and healthy volunteers. Hum Psychopharmacol 2011 Dec 2
36 22160164 Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 2012 Jun 1
37 22191083 Agomelatine: a novel antidepressant. Innov Clin Neurosci 2011 Nov 1
38 22335516 Emerging targets for the pharmacological treatment of depression: focus on melatonergic system. Curr Med Chem 2012 4
39 22647752 The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala. Brain Res 2012 Jul 23 1
40 22867907 Synergistic mechanisms involved in the antidepressant effects of agomelatine. Eur Neuropsychopharmacol 2012 2
41 23262445 Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands. Molecules 2012 Dec 24 2
42 23530731 Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: a critical review. World J Biol Psychiatry 2013 Aug 2
43 23584358 Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats. Hum Exp Toxicol 2013 Aug 2
44 23650464 Mood disorders, circadian rhythms, melatonin and melatonin agonists. J Cent Nerv Syst Dis 2012 1
45 23663281 Economic evaluation of agomelatine relative to other antidepressants for treatment of major depressive disorders in Greece. BMC Health Serv Res 2013 May 10 1
46 23719026 On 'polypharmacy' and multi-target agents, complementary strategies for improving the treatment of depression: a comparative appraisal. Int J Neuropsychopharmacol 2014 Jul 2
47 23768699 Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. Kaohsiung J Med Sci 2013 Jul 3
48 23801192 Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol 2013 Aug 1
49 23983944 Agomelatine in unipolar depression in clinical practice: a retrospective chart review. Ther Adv Psychopharmacol 2011 Dec 4
50 24031039 Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 /MT2 agonist and 5-HT2C antagonist. ChemMedChem 2013 Nov 3