Title : The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways.

Pub. Date : 2003 Sep

PMID : 12750432






2 Functional Relationships(s)
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1 In conclusion, in contrast to melatonin, agomelatine behaves as an antagonist at 5-HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission. agomelatine 5-hydroxytryptamine receptor 2B Homo sapiens
2 In conclusion, in contrast to melatonin, agomelatine behaves as an antagonist at 5-HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission. agomelatine 5-hydroxytryptamine receptor 2C Homo sapiens