5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid






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1 25330112 Suppression of Foxo1 activity and down-modulation of CD62L (L-selectin) in HIV-1 infected resting CD4 T cells. PLoS One 2014 2
2 25483084 Targeting FoxO1 with AS1842856 suppresses adipogenesis. Cell Cycle 2014 3
3 25908760 Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol 2015 Jun 1
4 26239835 FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders? Curr Diabetes Rev 2016 1
5 26499800 Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem 2015 Dec 18 2
6 26577046 Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res 2016 Feb 5
7 27207509 Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes. Diabetes 2016 Aug 2
8 27260854 FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell Cycle 2016 Aug 2 4
9 27363949 mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacol Res 2016 Sep 2
10 28215713 TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4. Biochim Biophys Acta Mol Cell Biol Lipids 2017 May 2
11 28445821 The AMPK/mTOR pathway is involved in D-dopachrome tautomerase gene transcription in adipocytes differentiated from SGBS cells, a human preadipocyte cell line. Cytokine 2017 Aug 2
12 28687587 FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression. Am J Physiol Heart Circ Physiol 2017 Sep 1 2
13 28888048 Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression. J Cell Physiol 2018 Apr 3
14 29157981 FoxO1 inhibition promotes differentiation of human embryonic stem cells into insulin producing cells. Exp Cell Res 2018 Jan 1 4
15 29339772 Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy. Sci Rep 2018 Jan 16 1
16 29654945 FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission. Biochim Biophys Acta Mol Basis Dis 2018 Jul 1
17 29727907 Pancreatic Beta-Cell Proliferation Induced by Estradiol-17β is Foxo1 Dependent. Horm Metab Res 2018 Jun 4
18 29891553 CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1. J Immunol 2018 Jul 15 1
19 29929978 Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. J Biol Chem 2018 Aug 24 2
20 30186875 Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. J Diabetes Res 2018 2
21 30488666 FAM3B (PANDER) functions as a co-activator of FOXO1 to promote gluconeogenesis in hepatocytes. J Cell Mol Med 2019 Mar 3
22 30597041 Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. Endocrinology 2019 Feb 1 3
23 30611853 Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury. Pharmacol Res 2019 Mar 2
24 30944148 Forkhead box O1 (FOXO1) controls the migratory response of Toll-like receptor (TLR3)-stimulated human mesenchymal stromal cells. J Biol Chem 2019 May 24 2
25 30967498 The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep 2019 May 31 2
26 30988014 Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression. Mol Pharmacol 2019 Jun 1
27 31042779 FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction. PLoS Pathog 2019 May 5
28 31085234 Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade. Cell Signal 2019 Sep 4
29 31146723 Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway. BMC Complement Altern Med 2019 May 30 2
30 31202735 Nodal pathway activation due to Akt1 suppression is a molecular switch for prostate cancer cell epithelial-to-mesenchymal transition and metastasis. Biochem Pharmacol 2019 Oct 1
31 31298345 Loss of microRNA-27a induces cardiac dysfunction through activating FoxO1. Eur Rev Med Pharmacol Sci 2019 Jul 1
32 32075913 Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. J Biol Chem 2020 Mar 27 1
33 32197645 High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells. Stem Cell Res Ther 2020 Mar 20 1
34 32218743 Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis. Front Physiol 2020 1
35 32304578 Ethanol Inhibits Mesenchymal Stem Cell Osteochondral Lineage Differentiation Due in Part to an Activation of Forkhead Box Protein O-Specific Signaling. Alcohol Clin Exp Res 2020 Jun 1
36 32450616 FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetes. J Cell Mol Med 2020 Jul 1
37 32808351 MicroRNA-182 exacerbates blood-brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia. FASEB J 2020 Oct 4
38 33049085 Bone marrow mesenchymal stem cells inhibit cardiac hypertrophy by enhancing FoxO1 transcription. Cell Biol Int 2021 Jan 1
39 33108705 Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats. J Cell Mol Med 2020 Dec 4
40 33577983 FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice. Mol Metab 2021 Jul 2
41 33594326 Clinical application of a FOXO1 inhibitor improves connective tissue healing in a diabetic minipig model. Am J Transl Res 2021 5
42 33722671 FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion. Cell Signal 2021 Jul 2
43 33826891 FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity. Cell Rep 2021 Apr 6 1
44 34163023 Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling. Acta Pharmacol Sin 2022 Mar 2
45 34233525 Megestrol acetate drives endometrial carcinoma cell senescence via interacting with progesterone receptor B/FOXO1 axis. Exp Biol Med (Maywood) 2021 Nov 2
46 34234507 Upregulation of COX-2 and PGE<sub>2</sub> Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. J Inflamm Res 2021 5
47 34403862 Regulation of autoreactive CD4 T cells by FoxO1 signaling in CNS autoimmunity. J Neuroimmunol 2021 Oct 15 3
48 34506757 SMC4 knockdown inhibits malignant biological behaviors of endometrial cancer cells by regulation of FoxO1 activity. Arch Biochem Biophys 2021 Nov 15 4
49 34513822 High-Mobility Group A1 Promotes Cardiac Fibrosis by Upregulating FOXO1 in Fibroblasts. Front Cell Dev Biol 2021 2
50 34522203 Angiotensin IV attenuates diabetic cardiomyopathy <i>via</i> suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis. Theranostics 2021 1