tamibarotene






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1 3133373 Inhibition of ornithine decarboxylase induction by retinobenzoic acids in relation to their binding affinities to cellular retinoid-binding proteins. J Cancer Res Clin Oncol 1988 4
2 7556191 Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. Eur J Biochem 1995 Sep 1 4
3 8549823 Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels. FEBS Lett 1996 Jan 8 1
4 9122888 Relation of TGF-beta 2 to inhibition of limb bud chondrogenesis by retinoid in rats. Teratology 1996 Oct 3
5 9873234 Effect of Am-80, a synthetic derivative of retinoid, on experimental arthritis in mice. Pharmacology 1999 Feb 4
6 10828746 Effect of Am-80, a retinoid derivative, on 2, 4-dinitrofluorobenzene-induced contact dermatitis in mice. Pharmacology 2000 May 9
7 11043609 The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats. Life Sci 2000 Sep 1 4
8 11233995 Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3. Life Sci 2001 Feb 2 1
9 11501064 Effect of selective IL-6 inhibitor Am-80 on experimental autoimmune encephalomyelitis in DA rats. Acta Pharmacol Sin 2000 Nov 4
10 11945126 Novel synthetic retinoids and separation of the pleiotropic retinoidal activities. Curr Med Chem 2002 Mar 1
11 15020266 Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression. Haematologica 2004 Mar 1
12 15498508 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol 2004 Dec 1 1
13 15703382 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol 2005 May 1
14 15843826 Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis. Leukemia 2005 Jun 1
15 16224062 Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res 2005 Nov 25 3
16 16484594 Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6. Arterioscler Thromb Vasc Biol 2006 May 5
17 16819260 [Retinoid therapy for autoimmune diseases]. Nihon Rinsho Meneki Gakkai Kaishi 2006 Jun 2
18 17170094 All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling. Endocrinology 2007 Mar 1
19 17229644 Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica 2007 Jan 2
20 17436592 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. In Vivo 2007 Mar-Apr 2
21 17611697 RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int J Oncol 2007 Aug 8
22 18404486 Upregulation of P2Y2 receptors by retinoids in normal human epidermal keratinocytes. Purinergic Signal 2006 Sep 1
23 18771528 Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene). Cancer Sci 2008 Nov 6
24 19182380 The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol Pharm Bull 2009 Feb 3
25 19292987 Synthetic retinoid Am80 inhibits interaction of KLF5 with RAR alpha through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells. FEBS Lett 2009 Apr 17 21
26 19450544 The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction. Biochim Biophys Acta 2009 Sep 2
27 19457078 Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. J Neurochem 2009 Jul 4
28 19514122 Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells. Cancer Sci 2009 Jun 1
29 19531492 Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem 2009 Aug 21 2
30 19571405 Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice. Biol Pharm Bull 2009 Jul 4
31 19952418 Disposition of a new tamibarotene prodrug in mice. Biol Pharm Bull 2009 Dec 2
32 20141446 Am80 inhibits stromal cell-derived factor-1-induced chemotaxis in T-cell acute lymphoblastic leukemia cells. Leuk Lymphoma 2010 Mar 1
33 20551971 A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 2011 Jan 5
34 20649843 Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF. J Neurochem 2011 Feb 5
35 21393419 All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. J Leukoc Biol 2011 Aug 8
36 22021245 Fluorescence spectrometric study on the interaction of tamibarotene with bovine serum albumin. Luminescence 2011 Sep-Oct 2
37 22301853 Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein. Neurodegener Dis 2012 1
38 22465180 Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice. Eur J Pharmacol 2012 May 15 2
39 22531980 Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice. Hepatology 2012 Oct 3
40 22863914 Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull 2012 6
41 22864348 [Retinoids as promising treatment for non-alcoholic fatty liver disease]. Yakugaku Zasshi 2012 3
42 23124249 Am80 induces neuronal differentiation via increased tropomyosin-related kinase B expression in a human neuroblastoma SH-SY5Y cell line. Biomed Res 2012 4
43 23243275 Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model. Blood 2013 Feb 7 3
44 23404745 A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver. Obesity (Silver Spring) 2013 Jan 2
45 23624141 The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology 2013 Sep 4
46 24204796 All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation. PLoS One 2013 2
47 24659080 Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice. J Neurosci Res 2014 Aug 3
48 24994461 Retinoic acid acts as a selective human IgA switch factor. Hum Immunol 2014 Aug 1
49 25807265 Activity analysis and preliminary inducer screening of the chicken DAZL gene promoter. Int J Mol Sci 2015 Mar 23 4
50 26202410 An open-label phase I/II study of tamibarotene in patients with advanced hepatocellular carcinoma. Hepatol Int 2014 Jan 1