Title : Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF.

Pub. Date : 2011 Feb

PMID : 20649843






5 Functional Relationships(s)
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1 Am80-induced increase in BDNF expression was observed in dopaminergic neurons, which was blocked by inhibition of extracellular signal-regulated kinase (ERK) activation. tamibarotene brain-derived neurotrophic factor Rattus norvegicus
2 Am80-induced increase in BDNF expression was observed in dopaminergic neurons, which was blocked by inhibition of extracellular signal-regulated kinase (ERK) activation. tamibarotene Eph receptor B1 Rattus norvegicus
3 Am80-induced increase in BDNF expression was observed in dopaminergic neurons, which was blocked by inhibition of extracellular signal-regulated kinase (ERK) activation. tamibarotene Eph receptor B1 Rattus norvegicus
4 Notably, the effect of Am80 on BDNF expression was attenuated by inhibitors of nitric oxide synthase, soluble guanylyl cyclase and cyclic GMP-dependent protein kinase (PKG). tamibarotene brain-derived neurotrophic factor Rattus norvegicus
5 Am80-induced ERK phosphorylation in dopaminergic neurons was also attenuated by inhibition of soluble guanylyl cyclase and PKG. tamibarotene Eph receptor B1 Rattus norvegicus