Title : Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells.

Pub. Date : 2009 Aug 21

PMID : 19531492






2 Functional Relationships(s)
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1 We demonstrated that Klf4 directly binds to the 5" regulatory region of RAR alpha, down-regulates RAR alpha expression, and specifically inhibits RAR alpha-mediated phosphatidylinositol 3-kinase (PI3K) and ERK signaling in cultured VSMCs induced by the synthetic retinoid Am80. tamibarotene Kruppel like factor 4 Homo sapiens
2 We demonstrated that Klf4 directly binds to the 5" regulatory region of RAR alpha, down-regulates RAR alpha expression, and specifically inhibits RAR alpha-mediated phosphatidylinositol 3-kinase (PI3K) and ERK signaling in cultured VSMCs induced by the synthetic retinoid Am80. tamibarotene retinoic acid receptor alpha Homo sapiens