5-hydroxymethyluracil






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1 3258829 [Effect of hydroxymethyluracil on the course of experimental pancreatitis in the rat]. Farmakol Toksikol 1988 Jan-Feb 1
2 3739226 The phage SPO1-specific RNA polymerase, E.gp28, recognizes its cognate promoters in thymine-containing DNA. Virology 1986 Aug 1
3 4206941 Early biochemical events occurring after infection of Bacillus cereus 569-SP1 with bacteriophage GSW. J Virol 1974 Apr 1
4 6438630 Sequence of the bacteriophage SP01 gene coding for transcription factor 1, a viral homologue of the bacterial type II DNA-binding proteins. Proc Natl Acad Sci U S A 1984 Nov 3
5 7732378 Prebiotic synthesis of 5-substituted uracils: a bridge between the RNA world and the DNA-protein world. Science 1995 May 5 1
6 8107099 Interrelations of secondary structure stability and DNA-binding affinity in the bacteriophage SPO1-encoded type II DNA-binding protein TF1. J Mol Biol 1994 Feb 11 2
7 8764400 On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1. J Mol Biol 1996 Jul 12 3
8 8824510 Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis 1996 Sep 1
9 9148920 Twin hydroxymethyluracil-A base pair steps define the binding site for the DNA-binding protein TF1. J Biol Chem 1997 May 16 2
10 11159757 Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53. Carcinogenesis 2001 Jan 1
11 11526119 Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. J Biol Chem 2001 Nov 9 1
12 12056890 The role of surface-exposed lysines in wrapping DNA about the bacterial histone-like protein HU. Biochemistry 2002 Jun 18 2
13 12161446 hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. J Biol Chem 2002 Oct 18 2
14 12718543 Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Biochemistry 2003 May 6 1
15 12820976 Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell 2003 Jun 3
16 12873134 Surface salt bridges modulate DNA wrapping by the type II DNA-binding protein TF1. Biochemistry 2003 Jul 29 2
17 14642566 The transcription factor, NFI/CTF plays a positive regulatory role in expression of the hSMUG1 gene. DNA Repair (Amst) 2003 Dec 9 1
18 15466595 Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Nucleic Acids Res 2004 7
19 15533839 DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells. DNA Repair (Amst) 2005 Jan 2 2
20 17116429 Uracil in DNA--general mutagen, but normal intermediate in acquired immunity. DNA Repair (Amst) 2007 Apr 1 1
21 17389644 The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res 2007 2
22 17590428 DNA-uracil and human pathology. Mol Aspects Med 2007 Jun-Aug 4
23 21161052 Opposite effects of 5-hydroxymethyluracil on mitogenic response of T cells stimulated through T-cell receptor or through T-cell receptor and CD28 co-receptor molecule. Bull Exp Biol Med 2010 Dec 1
24 21722948 Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 2011 Jul 8 2
25 22447450 Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Nucleic Acids Res 2012 Jul 1
26 22740654 Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res 2012 Sep 1 4
27 22962365 Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res 2012 Nov 1 3
28 23337108 Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol 2013 Mar 25 4
29 24055867 Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks? Mutat Res Genet Toxicol Environ Mutagen 2014 Apr 2
30 24746924 Error-free versus mutagenic processing of genomic uracil--relevance to cancer. DNA Repair (Amst) 2014 Jul 1
31 25946119 Selective Chemical Labeling of Natural T Modifications in DNA. J Am Chem Soc 2015 Jul 29 1
32 26358812 Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res 2015 Oct 30 2
33 27036066 Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both? Mutat Res Rev Mutat Res 2016 Jan-Mar 5
34 27493500 Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG. Biophysics (Nagoya-shi) 2014 4
35 28775312 Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Sci Rep 2017 Aug 3 1
36 29717169 UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Sci Rep 2018 May 1 4
37 31820932 Tandem Lesions Arising from 5-(Uracilyl)methyl Peroxyl Radical Addition to Guanine: Product Analysis and Mechanistic Studies. Chem Res Toxicol 2020 Feb 17 2
38 31986025 Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. J Am Chem Soc 2020 Feb 12 1
39 32822019 Evidence for Noncytosine Epigenetic DNA Modifications in Multicellular Eukaryotes: An Overview. Methods Mol Biol 2021 1
40 32866463 Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein. Anal Biochem 2020 Dec 1 2
41 34107280 Structural Insights into the Mechanism of Base Excision by MBD4. J Mol Biol 2021 Jul 23 1