isoquinoline






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1 360759 Dopaminergic agonist Ro 8-4650 in Parkinson's disease. I. Patients treated with dopa. Acta Neurol Scand 1978 Jul 1
2 1473250 Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro. Carcinogenesis 1992 Dec 1
3 1649835 Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J Biol Chem 1991 Jul 25 4
4 1883525 Regulation of M-CSF expression by M-CSF: role of protein kinase C and transcription factor NF kappa B. Pathobiology 1991 3
5 2037868 Protein ligand interactions:isoquinoline alkaloids as inhibitors for lactate and malate dehydrogenase. J Enzyme Inhib 1991 2
6 2196173 Colony-stimulating factor 1 activates protein kinase C in human monocytes. EMBO J 1990 Aug 1
7 2821259 Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one. J Med Chem 1987 Oct 1
8 2892200 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate. Proc R Soc Lond B Biol Sci 1987 Sep 22 1
9 3346669 Inhibition of type A monoamine oxidase by methylquinolines and structurally related compounds. J Neurochem 1988 Apr 1
10 3821373 Quinoline and quninaldine as naturally occurring inhibitors specific for type A monoamine oxidase. Life Sci 1987 Mar 16 1
11 5072367 Inability of isoquinoline derivatives to inhibit virus neuraminidase activity. J Gen Virol 1972 Aug 1
12 7516040 The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol 1994 Mar 1
13 7542903 Hormonal regulation of peripheral-type benzodiazepine receptors. J Steroid Biochem Mol Biol 1995 Jun 2
14 7662887 Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuroreport 1995 May 30 1
15 7841044 Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands. Br J Cancer 1995 Feb 1
16 8575032 Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structrue-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides. Chem Pharm Bull (Tokyo) 1995 Nov 1
17 8630091 Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration. Biochem Pharmacol 1996 Jun 14 1
18 8691425 Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. J Med Chem 1996 Jun 7 1
19 8839983 Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives. Biol Chem Hoppe Seyler 1996 Jun 2
20 8875598 Pharmacological characteristics of BDTI, a new isoquinoline-derived beta 2-adrenoceptor agonist, in canine trachea and rat heart. Pharmacology 1996 Jul 1
21 9101367 Role of protein kinase A in collagenase-1 gene regulation by prostaglandin E1: studies in a rabbit synoviocyte cell line, HIG-82. J Bone Miner Res 1997 Apr 1
22 9113369 The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol 1997 Apr 1
23 9401954 Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products. J Pharm Pharmacol 1997 Nov 1
24 9527511 Characterization of binding sites for the omega3 receptor ligands [3H]PK11195 and [3H]RO5-4864 in human brain. Eur J Pharmacol 1997 Dec 4 1
25 9711973 Biochemical aspects of Parkinson's disease. Neurology 1998 Aug 1
26 9767636 A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives. J Med Chem 1998 Oct 8 1
27 9767637 A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. J Med Chem 1998 Oct 8 1
28 9918542 Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness. J Pharmacol Exp Ther 1999 Feb 2
29 10353597 Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene 1999 Apr 22 1
30 10364850 Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Med 1999 May 1
31 10813936 Synthesis and conformational study of 1,3,2-oxazaphosphorino[4, 3-a]isoquinolines: a new ring system. J Org Chem 2000 Jan 28 1
32 10841801 Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor. J Med Chem 2000 Jun 1 2
33 10854431 Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor. J Biol Chem 2000 Sep 1 1
34 11128601 Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl. J Neural Transm Suppl 2000 1
35 11237767 Identification of a novel inhibitor of LPS-induced TNF-alpha production with antiproliferative activity in monocyte/macrophages. Biochem Biophys Res Commun 2001 Mar 9 1
36 11520893 Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol. J Neurochem 2001 Aug 1
37 11689087 Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 2001 Nov 8 2
38 11861809 The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase. J Pharmacol Exp Ther 2002 Mar 1
39 11911843 Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. Biochem Pharmacol 2002 Mar 1 1
40 11948256 PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. J Neurochem 2002 Mar 2
41 12161135 Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines. Bioorg Med Chem Lett 2002 Sep 2 1
42 12353998 Synthesis of 3-substituted 4-aroylisoquinolines via Pd-catalyzed carbonylative cyclization of 2-(1-alkynyl)benzaldimines. J Org Chem 2002 Oct 4 2
43 12382020 PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. Neoplasma 2002 2
44 12657723 Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design. Mol Cancer Ther 2003 Mar 1
45 12798691 Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). J Mol Biol 2003 Jun 20 1
46 14649722 Structural specificity for the inhibitory effect of calmodulin on specific 125I-omega-conotoxin GVIA binding. Neurochem Res 2003 Dec 1
47 14723961 Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands. Bioorg Med Chem 2004 Jan 15 1
48 15210579 Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor. Br J Pharmacol 2004 Jul 1
49 15531802 Electrospray tandem mass spectrometry for structural characterization of aporphine- benzylisoquinoline alkaloids. Eur J Mass Spectrom (Chichester) 2004 1
50 15664838 Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett 2005 Feb 1 4