Title : Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

Pub. Date : 2004 Jul

PMID : 15210579






1 Functional Relationships(s)
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1 2 Both ATP and the nucleotide analogue 2"-3"-O-(4-benzoylbenzoyl)-ATP (BzATP) induced an 86Rb+ efflux, which was completely inhibited by the isoquinoline derivative 1-(N,O-bis[5-isoquinolinesulphonyl]-N-methyl-l-tyrosyl)-4-phenylpiperazine (KN-62), a potent P2X7 receptor antagonist. isoquinoline purinergic receptor P2X 7 Homo sapiens