N-(3-(aminomethyl)benzyl)acetamidine






55 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 9030556 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997 Feb 21 2
2 9242464 Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res 1997 Aug 1 3
3 9667974 N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem 1998 Jul 16 2
4 9754916 Protective effect of N-(3-(aminomethyl)benzyl) acetamidine, an inducible nitric oxide synthase inhibitor, in brain slices exposed to oxygen-glucose deprivation. Eur J Pharmacol 1998 Aug 7 2
5 10385257 Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br J Pharmacol 1999 May 2
6 10868937 Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase. Diabetes 2000 Feb 2
7 11046081 Role of inducible nitric-oxide synthase in regulation of whole-cell current in lung epithelial cells. J Pharmacol Exp Ther 2000 Nov 2
8 11061981 Allergic airway hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS inhibitor, 1400W, in mice. Pulm Pharmacol Ther 2000 1
9 11459438 N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats. Life Sci 2001 Jun 15 1
10 11504810 Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. J Pharmacol Exp Ther 2001 Sep 2
11 11709391 Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO*. Am J Physiol Heart Circ Physiol 2001 Dec 1
12 11773322 Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice. J Physiol 2002 Jan 1 1
13 11790707 Role of myocardial inducible nitric oxide synthase in contractile dysfunction and beta-adrenergic hyporesponsiveness in rats with experimental volume-overload heart failure. Circulation 2002 Jan 15 1
14 11970856 N-Acetylcysteine negatively modulates nitric oxide production in endotoxin-treated rats through inhibition of NF-kappaB activation. Antioxid Redox Signal 2002 Feb 2
15 12020693 Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects. Eur J Pharmacol 2002 May 3 1
16 12506043 Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. J Appl Physiol (1985) 2003 Apr 2
17 12789530 Highly selective inhibitor of inducible nitric oxide synthase enhances S-antigen-induced uveitis. Curr Eye Res 2003 Jan 2
18 12969613 Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase. Resuscitation 2003 Sep 1
19 14664711 Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells. J Mol Endocrinol 2003 Dec 3
20 14707269 Nitric oxide does not mediate but inhibits transformation and tumor phenotype. Mol Cancer Ther 2003 Dec 1
21 14744612 Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes. Eur J Pharmacol 2004 Jan 26 1
22 14977638 Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth. Am J Physiol Gastrointest Liver Physiol 2004 Jul 2
23 15187170 The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids. J Pharmacol Exp Ther 2004 Oct 2
24 15279652 Effects of an inducible nitric oxide synthase inhibitor on experimentally induced rat pulpitis. Eur J Oral Sci 2004 Aug 1
25 15582451 Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor. Bioorg Med Chem 2005 Jan 3 2
26 15643549 Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats. Planta Med 2004 Dec 2
27 15656623 Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. J Am Chem Soc 2005 Jan 26 1
28 15800493 Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration. Surgery 2005 Apr 1
29 15880470 Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle. Microsurgery 2005 1
30 16183707 Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries. J Pharmacol Exp Ther 2006 Jan 1
31 16257923 Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Am J Physiol Gastrointest Liver Physiol 2006 Apr 1
32 16537416 Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Proc Natl Acad Sci U S A 2006 Mar 21 3
33 16574780 Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress. J Pharmacol Exp Ther 2006 Aug 4
34 16600210 Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing. Eur J Pharmacol 2006 May 1 2
35 16700724 Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice. Neurogastroenterol Motil 2006 Jun 1
36 17197099 Endomorphin 1 activates nitric oxide synthase 2 activity and downregulates nitric oxide synthase 2 mRNA expression. Neuroscience 2007 Feb 23 1
37 17510837 Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles. Inhal Toxicol 2007 Jun 3
38 17538970 Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology 2007 Jun 2
39 17976576 Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats. Eur J Pharmacol 2008 Jan 28 1
40 18063323 Selective iNOS inhibition reduces renal damage induced by cisplatin. Toxicol Lett 2008 Jan 4 1
41 18257661 Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart. Rejuvenation Res 2008 Feb 2
42 18297608 Nitric oxide protection against adriamycin-induced tubulointerstitial injury. Free Radic Res 2008 Feb 2
43 19203270 Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase. J Med Chem 2009 Mar 12 2
44 19270191 Hindlimb ischemia/reperfusion-induced remote injury to the small intestine: role of inducible nitric-oxide synthase-derived nitric oxide. J Pharmacol Exp Ther 2009 Jun 1
45 20188080 Calreticulin transacetylase catalyzed modification of the TNF-alpha mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates. Chem Biol Interact 2010 May 14 1
46 20418118 Does inducible NOS have a protective role against hypoxia/reoxygenation injury in rat heart? Cardiovasc Pathol 2011 Jan-Feb 1
47 20549418 Effect of 1400W on blocking lipopolysaccharide-induced microglial toxicity to preoligodendrocytes. World J Pediatr 2010 Aug 1
48 20619352 Role of carbon monoxide and nitric oxide in adult rat hepatocytes proliferating in vitro: Effects of CAS 1609. Nitric Oxide 2010 Nov 1 1
49 20648920 Lipopolysaccharide-induced impairment of nitric oxide-mediated vasorelaxation and protective effects of nitric oxide synthesis inhibitors in isolated rat mesenteric arteries. Arzneimittelforschung 2010 1
50 22531370 Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. J Neuroinflammation 2012 Jul 6 1