Title : Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.

Pub. Date : 2005 Jan 26

PMID : 15656623






1 Functional Relationships(s)
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1 N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was reported to be a slow, tight-binding, and highly selective inhibitor of iNOS in vitro and in vivo. N-(3-(aminomethyl)benzyl)acetamidine nitric oxide synthase 2 Homo sapiens