Title : Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine.

Pub. Date : 2001 Sep

PMID : 11504810






2 Functional Relationships(s)
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1 Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. N-(3-(aminomethyl)benzyl)acetamidine nitric oxide synthase 2 Rattus norvegicus
2 The aim of the present study was to investigate the effects of a novel highly selective iNOS inhibitor, N-[3-(aminomethyl)benzyl]acetamidine (1400W), as compared with a nonselective NOS inhibitor, N(G)-nitro-L-arginine-methyl-ester (L-NAME), in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis in the rat. N-(3-(aminomethyl)benzyl)acetamidine nitric oxide synthase 2 Rattus norvegicus