Pub. Date : 1998 Dec
PMID : 9871099
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats. | Iodine-123 | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 2 | Iodine-123 labelled 2beta-carbomethoxy-3beta-4-iodophenylnortropane (nor-beta-CIT), a radioiodinated cocaine analogue, was evaluated as an agent for the in vivo labelling of serotonin transporters by biodistribution studies in rats. | Iodine-123 | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 3 | Iodine-123 labelled 2beta-carbomethoxy-3beta-4-iodophenylnortropane (nor-beta-CIT), a radioiodinated cocaine analogue, was evaluated as an agent for the in vivo labelling of serotonin transporters by biodistribution studies in rats. | 2beta-carbomethoxy-3beta-4-iodophenylnortropane | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 4 | Intravenous injection of [123I]nor-beta-CIT resulted in high accumulation of radioactivity in brain areas with high densities of serotonin (hypothalamus) and dopamine transporters (striatum), although the binding was less pronounced in the hypothalamus. | Iodine-123 | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 5 | Intravenous injection of [123I]nor-beta-CIT resulted in high accumulation of radioactivity in brain areas with high densities of serotonin (hypothalamus) and dopamine transporters (striatum), although the binding was less pronounced in the hypothalamus. | Serotonin | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 6 | While binding of [123I]nor-beta-CIT in the hypothalamus was blocked significantly by fluvoxamine (a selective serotonin transporter blocker) but not by GBR12,909 (a selective dopamine transporter blocker), the opposite was observed in the striatum. | Fluvoxamine | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 7 | The results of this study indicate that [123I]nor-beta-CIT, although not being a selective radioligand, binds specifically to serotonin transporters in the hypothalamus in vivo and thus suggest that [123I]nor-beta-CIT promises to be a suitable radioligand for single-photon emission tomography imaging of serotonin transporters in humans. | Iodine-123 | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 8 | The results of this study indicate that [123I]nor-beta-CIT, although not being a selective radioligand, binds specifically to serotonin transporters in the hypothalamus in vivo and thus suggest that [123I]nor-beta-CIT promises to be a suitable radioligand for single-photon emission tomography imaging of serotonin transporters in humans. | Iodine-123 | citron rho-interacting serine/threonine kinase | Rattus norvegicus |