PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9871099-0 1998 Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats. Iodine-123 0-10 citron rho-interacting serine/threonine kinase Rattus norvegicus 29-32 9871099-0 1998 Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats. Iodine-123 0-10 solute carrier family 6 member 4 Rattus norvegicus 46-67 9871099-1 1998 Iodine-123 labelled 2beta-carbomethoxy-3beta-4-iodophenylnortropane (nor-beta-CIT), a radioiodinated cocaine analogue, was evaluated as an agent for the in vivo labelling of serotonin transporters by biodistribution studies in rats. Iodine-123 0-10 citron rho-interacting serine/threonine kinase Rattus norvegicus 78-81 9871099-1 1998 Iodine-123 labelled 2beta-carbomethoxy-3beta-4-iodophenylnortropane (nor-beta-CIT), a radioiodinated cocaine analogue, was evaluated as an agent for the in vivo labelling of serotonin transporters by biodistribution studies in rats. 2beta-carbomethoxy-3beta-4-iodophenylnortropane 20-67 citron rho-interacting serine/threonine kinase Rattus norvegicus 78-81 9871099-2 1998 Intravenous injection of [123I]nor-beta-CIT resulted in high accumulation of radioactivity in brain areas with high densities of serotonin (hypothalamus) and dopamine transporters (striatum), although the binding was less pronounced in the hypothalamus. Iodine-123 26-30 citron rho-interacting serine/threonine kinase Rattus norvegicus 40-43 9871099-2 1998 Intravenous injection of [123I]nor-beta-CIT resulted in high accumulation of radioactivity in brain areas with high densities of serotonin (hypothalamus) and dopamine transporters (striatum), although the binding was less pronounced in the hypothalamus. Serotonin 129-138 citron rho-interacting serine/threonine kinase Rattus norvegicus 40-43 9871099-3 1998 While binding of [123I]nor-beta-CIT in the hypothalamus was blocked significantly by fluvoxamine (a selective serotonin transporter blocker) but not by GBR12,909 (a selective dopamine transporter blocker), the opposite was observed in the striatum. Fluvoxamine 85-96 citron rho-interacting serine/threonine kinase Rattus norvegicus 32-35 9871099-3 1998 While binding of [123I]nor-beta-CIT in the hypothalamus was blocked significantly by fluvoxamine (a selective serotonin transporter blocker) but not by GBR12,909 (a selective dopamine transporter blocker), the opposite was observed in the striatum. Fluvoxamine 85-96 solute carrier family 6 member 4 Rattus norvegicus 110-131 9871099-4 1998 The results of this study indicate that [123I]nor-beta-CIT, although not being a selective radioligand, binds specifically to serotonin transporters in the hypothalamus in vivo and thus suggest that [123I]nor-beta-CIT promises to be a suitable radioligand for single-photon emission tomography imaging of serotonin transporters in humans. Iodine-123 41-45 citron rho-interacting serine/threonine kinase Rattus norvegicus 55-58 9871099-4 1998 The results of this study indicate that [123I]nor-beta-CIT, although not being a selective radioligand, binds specifically to serotonin transporters in the hypothalamus in vivo and thus suggest that [123I]nor-beta-CIT promises to be a suitable radioligand for single-photon emission tomography imaging of serotonin transporters in humans. Iodine-123 200-204 citron rho-interacting serine/threonine kinase Rattus norvegicus 55-58