Pub. Date : 1998 Nov
PMID : 9840430
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At a clozapine concentration of 20 microM, the rate of formation of clozapine N-oxide showed significant correlations with activities of CYP3A4 (P<0.01) and CYP1A2 (P<0.05). | clozapine N-oxide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | At a clozapine concentration of 20 microM, the rate of formation of clozapine N-oxide showed significant correlations with activities of CYP3A4 (P<0.01) and CYP1A2 (P<0.05). | clozapine N-oxide | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | By combining the results of the current study and those reported in the literature, it is proposed that CYP3A4 and FMO3 are primarily responsible for the production of clozapine N-oxide, and CYP3A4 and CYP1A2 are primarily responsible for the formation of N-desmethylclozapine. | clozapine N-oxide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | By combining the results of the current study and those reported in the literature, it is proposed that CYP3A4 and FMO3 are primarily responsible for the production of clozapine N-oxide, and CYP3A4 and CYP1A2 are primarily responsible for the formation of N-desmethylclozapine. | clozapine N-oxide | flavin containing dimethylaniline monoxygenase 3 | Homo sapiens |