Pub. Date : 1998 Jun 1
PMID : 9596679
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. | Arsenic Trioxide | PML nuclear body scaffold | Homo sapiens |
| 2 | In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. | Arsenic Trioxide | PML nuclear body scaffold | Homo sapiens |
| 3 | When grown in the presence of As2O3, NB4-AsR cells degrade PML/RARalpha, slightly differentiate, and become more sensitive to serum deprivation-induced apoptosis. | Arsenic Trioxide | PML nuclear body scaffold | Homo sapiens |
| 4 | Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. | Arsenic Trioxide | PML nuclear body scaffold | Homo sapiens |
| 5 | Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 6 | Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. | Tretinoin | PML nuclear body scaffold | Homo sapiens |