PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9596679-1 1998 In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. Arsenic Trioxide 92-108 PML nuclear body scaffold Homo sapiens 225-228 9596679-1 1998 In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. Arsenic Trioxide 92-108 retinoic acid receptor alpha Homo sapiens 229-237 9596679-1 1998 In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. Arsenic Trioxide 110-115 PML nuclear body scaffold Homo sapiens 225-228 9596679-1 1998 In the acute promyelocytic leukemia (APL) cell line NB4, as well as in APL patients" cells, arsenic trioxide (As2O3) leads to incomplete cell maturation, induction of apoptosis, as well as to the degradation of the oncogenic PML/RARalpha fusion protein. Arsenic Trioxide 110-115 retinoic acid receptor alpha Homo sapiens 229-237 9596679-3 1998 When grown in the presence of As2O3, NB4-AsR cells degrade PML/RARalpha, slightly differentiate, and become more sensitive to serum deprivation-induced apoptosis. Arsenic Trioxide 30-35 PML nuclear body scaffold Homo sapiens 59-62 9596679-3 1998 When grown in the presence of As2O3, NB4-AsR cells degrade PML/RARalpha, slightly differentiate, and become more sensitive to serum deprivation-induced apoptosis. Arsenic Trioxide 30-35 retinoic acid receptor alpha Homo sapiens 63-71 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Arsenic Trioxide 6-11 PML nuclear body scaffold Homo sapiens 43-46 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Arsenic Trioxide 6-11 retinoic acid receptor alpha Homo sapiens 47-55 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Tretinoin 16-29 PML nuclear body scaffold Homo sapiens 43-46 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Tretinoin 16-29 retinoic acid receptor alpha Homo sapiens 47-55 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Tretinoin 31-33 PML nuclear body scaffold Homo sapiens 43-46 9596679-5 1998 Thus, As2O3- or retinoic acid (RA)-induced PML/RARalpha degradation may be a prerequisite, but is not sufficient for the full differentiative/apoptotic response to these drugs. Tretinoin 31-33 retinoic acid receptor alpha Homo sapiens 47-55