Pub. Date : 1998 Apr
PMID : 9584328
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recombinant CYP3A5 enzyme had higher activity in oxybutynin N-deethylation than recombinant CYP3A4. | oxybutynin n | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5. | Ketoconazole | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5. | Ketoconazole | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5. | oxybutynin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | Although the reasons for the weak and variable inhibition by itraconazole remain to be studied, it seems that oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6. | oxybutynin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |