PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9584328-3	1998	Oxybutynin N-deethylation in human liver microsomes in vitro was potently inhibited by ketoconazole (IC50 4.5 microM), less and variably by itraconazole and not by quinidine or several other reference inhibitors, suggesting that CYP3A enzymes are predominant catalysts of the reaction.	oxybutynin	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	229-234	
9584328-4	1998	Recombinant CYP3A5 enzyme had higher activity in oxybutynin N-deethylation than recombinant CYP3A4.	oxybutynin n	49-61	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	12-18	
9584328-4	1998	Recombinant CYP3A5 enzyme had higher activity in oxybutynin N-deethylation than recombinant CYP3A4.	oxybutynin n	49-61	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-98	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	Ketoconazole	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	Ketoconazole	0-12	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	79-85	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	Ketoconazole	0-12	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	186-192	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	oxybutynin	23-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	oxybutynin	23-33	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	79-85	
9584328-5	1998	Ketoconazole inhibited oxybutynin N-deethylation by the recombinant CYP3A4 and CYP3A5 almost completely, whereas itraconazole inhibited the activity of CYP3A4 more potently than that of CYP3A5.	Itraconazole	113-125	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158	
9584328-6	1998	Oxybutynin inhibited CYP3A4- and CYP2D6- associated activities (testosterone 6 beta-hydroxylase and dextromethorphan O- demethylase, respectively) in human liver microsomes.	oxybutynin	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27	
9584328-6	1998	Oxybutynin inhibited CYP3A4- and CYP2D6- associated activities (testosterone 6 beta-hydroxylase and dextromethorphan O- demethylase, respectively) in human liver microsomes.	oxybutynin	0-10	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	33-39	
9584328-7	1998	CYP1A1/2-, CYP2A6-, CYP2C9- and CYP2E1-associated activities were inhibited less potently or not at all by oxybutynin when compared with reference inhibitors.	oxybutynin	107-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
9584328-7	1998	CYP1A1/2-, CYP2A6-, CYP2C9- and CYP2E1-associated activities were inhibited less potently or not at all by oxybutynin when compared with reference inhibitors.	oxybutynin	107-117	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	11-17	
9584328-7	1998	CYP1A1/2-, CYP2A6-, CYP2C9- and CYP2E1-associated activities were inhibited less potently or not at all by oxybutynin when compared with reference inhibitors.	oxybutynin	107-117	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	20-26	
9584328-7	1998	CYP1A1/2-, CYP2A6-, CYP2C9- and CYP2E1-associated activities were inhibited less potently or not at all by oxybutynin when compared with reference inhibitors.	oxybutynin	107-117	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	32-38	
9584328-8	1998	Although the reasons for the weak and variable inhibition by itraconazole remain to be studied, it seems that oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6.	oxybutynin	110-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-159	
9584328-8	1998	Although the reasons for the weak and variable inhibition by itraconazole remain to be studied, it seems that oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6.	oxybutynin	110-120	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	164-170