Title : Transcriptional upregulation of retinoic acid receptor beta (RAR beta) expression by phenylacetate in human neuroblastoma cells.

Pub. Date : 1998 Feb 25

PMID : 9511735






4 Functional Relationships(s)
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1 Our studies indicated that NaPA can impact on the RA differentiation program by upregulating nuclear retinoic acid receptor-beta (RAR beta) expression. Acecainide retinoic acid receptor beta Homo sapiens
2 Our studies indicated that NaPA can impact on the RA differentiation program by upregulating nuclear retinoic acid receptor-beta (RAR beta) expression. Acecainide retinoic acid receptor beta Homo sapiens
3 In contrast, NaPA was able to specifically activate a reporter gene construct (delta SV beta RE-CAT) which contains a retinoic acid response element (RARE beta) that is located in the RAR beta promoter. Acecainide retinoic acid receptor beta Homo sapiens
4 Taken together, our findings suggest that induction of RAR beta by NaPA is regulated at the level of transcription and mediated through the retinoic acid response element, RARE beta. Acecainide retinoic acid receptor beta Homo sapiens