Pub. Date : 1998 Feb 19
PMID : 9486655
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, treatment with RA induces differentiation of leukaemic blast cells and disease remission in PML-RARalpha APLs, whereas PLZF-RARa APLs are resistant to RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | However, treatment with RA induces differentiation of leukaemic blast cells and disease remission in PML-RARalpha APLs, whereas PLZF-RARa APLs are resistant to RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | High doses of RA release histone deacetylase activity from PML-RARalpha, but not from PLZF-RARalpha. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 4 | Therefore, recruitment of histone deacetylase is crucial to the transforming potential of APL fusion proteins, and the different effects of RA on the stability of the PML-RARalpha and PLZF-RARalpha co-repressor complexes determines the differential response of APLs to RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 5 | Therefore, recruitment of histone deacetylase is crucial to the transforming potential of APL fusion proteins, and the different effects of RA on the stability of the PML-RARalpha and PLZF-RARalpha co-repressor complexes determines the differential response of APLs to RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |