Pub. Date : 1997 Sep 30
PMID : 9380739
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIV-1 specifically incorporates the peptidyl prolyl isomerase cyclophilin A (CyPA), the cytosolic receptor for the immunosuppressant cyclosporin A (CsA). | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 2 | HIV-1 specifically incorporates the peptidyl prolyl isomerase cyclophilin A (CyPA), the cytosolic receptor for the immunosuppressant cyclosporin A (CsA). | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 3 | HIV-1 replication is inhibited by CsA as well as by nonimmunosuppressive CsA analogues that bind to CyPA and interfere with its virion association. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 4 | We report here that the transfer of HIV-1 CA residues 86-93, which form part of an exposed loop, to the corresponding position in SIVmac resulted in the efficient incorporation of CyPA and conferred an HIV-1-like sensitivity to a nonimmunosuppressive cyclosporin. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 5 | By demonstrating that CyPA-binding-site residues can induce cyclosporin sensitivity in a heterologous context, this study provides direct in vivo evidence that the exposed loop between helices IV and V of HIV-1 CA not merely constitutes a docking site for CyPA but is a functional target of this cellular protein. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 6 | By demonstrating that CyPA-binding-site residues can induce cyclosporin sensitivity in a heterologous context, this study provides direct in vivo evidence that the exposed loop between helices IV and V of HIV-1 CA not merely constitutes a docking site for CyPA but is a functional target of this cellular protein. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |