Pub. Date : 1997 Oct 17
PMID : 9334201
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mice homozygous for a deletion in the gene for CEBPalpha (C/EBPalpha-/- mice) die shortly after birth of hypoglycemia, with no detectable hepatic PEPCK mRNA and negligible hepatic glycogen stores. | Glycogen | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus |
| 2 | Bt2cAMP induces PEPCK mRNA in the livers of fetal C/EBPalpha-/- mice, but at only 20% of the level of control animals; however, there is no induction of PEPCK mRNA if the cyclic nucleotide is injected into C/EBPalpha-/- mice immediately after delivery. | Bucladesine | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus |
| 3 | Bt2cAMP induces PEPCK mRNA in the livers of fetal C/EBPalpha-/- mice, but at only 20% of the level of control animals; however, there is no induction of PEPCK mRNA if the cyclic nucleotide is injected into C/EBPalpha-/- mice immediately after delivery. | Bucladesine | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus |
| 4 | The expression of the gene for C/EBPbeta is markedly induced in the livers of C/EBPalpha-/- mice within 2 h after the administration of Bt2cAMP. | Bucladesine | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus |
| 5 | We conclude that C/EBPalpha is required for the cAMP induction of PEPCK gene expression in the liver and that C/EBPbeta can compensate for the loss of C/EBPalpha if its concentration is induced to appropriate levels. | Cyclic AMP | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus |