PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9334201-2 1997 Mice homozygous for a deletion in the gene for CEBPalpha (C/EBPalpha-/- mice) die shortly after birth of hypoglycemia, with no detectable hepatic PEPCK mRNA and negligible hepatic glycogen stores. Glycogen 180-188 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 47-56 9334201-3 1997 Half of the mice homozygous for a deletion in the gene for CEBPbeta (C/EBPbeta-/- mice) have normal glucose homeostasis (phenotype A), and the other half die at birth of hypoglycemia due to a failure to express the gene for PEPCK and to mobilize hepatic glycogen (phenotype B). Glycogen 254-262 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 59-67 9334201-4 1997 Insulin deficiency induces C/EBPalpha and PEPCK gene transcription in the livers of 19-day fetal rats, whereas dibutyryl cyclic AMP (Bt2cAMP) increases the expression of the gene for C/EBPbeta and causes a transient burst of PEPCK mRNA. Bucladesine 111-131 CCAAT/enhancer binding protein beta Rattus norvegicus 183-192 9334201-4 1997 Insulin deficiency induces C/EBPalpha and PEPCK gene transcription in the livers of 19-day fetal rats, whereas dibutyryl cyclic AMP (Bt2cAMP) increases the expression of the gene for C/EBPbeta and causes a transient burst of PEPCK mRNA. Bucladesine 111-131 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 225-230 9334201-5 1997 Bt2cAMP induces PEPCK mRNA in the livers of fetal C/EBPalpha-/- mice, but at only 20% of the level of control animals; however, there is no induction of PEPCK mRNA if the cyclic nucleotide is injected into C/EBPalpha-/- mice immediately after delivery. Bucladesine 0-7 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 16-21 9334201-5 1997 Bt2cAMP induces PEPCK mRNA in the livers of fetal C/EBPalpha-/- mice, but at only 20% of the level of control animals; however, there is no induction of PEPCK mRNA if the cyclic nucleotide is injected into C/EBPalpha-/- mice immediately after delivery. Bucladesine 0-7 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 50-60 9334201-5 1997 Bt2cAMP induces PEPCK mRNA in the livers of fetal C/EBPalpha-/- mice, but at only 20% of the level of control animals; however, there is no induction of PEPCK mRNA if the cyclic nucleotide is injected into C/EBPalpha-/- mice immediately after delivery. Bucladesine 0-7 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 50-63 9334201-6 1997 The expression of the gene for C/EBPbeta is markedly induced in the livers of C/EBPalpha-/- mice within 2 h after the administration of Bt2cAMP. Bucladesine 136-143 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 31-40 9334201-6 1997 The expression of the gene for C/EBPbeta is markedly induced in the livers of C/EBPalpha-/- mice within 2 h after the administration of Bt2cAMP. Bucladesine 136-143 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 78-91 9334201-8 1997 In C/EBPbeta-/- mice with phenotype B, the administration of Bt2cAMP immediately after delivery induces PEPCK mRNA, causes the mobilization of hepatic glycogen, and maintains normal glucose homeostasis for up to 4 h (duration of the experiment). Glycogen 151-159 belted 2 Mus musculus 61-64 9334201-9 1997 We conclude that C/EBPalpha is required for the cAMP induction of PEPCK gene expression in the liver and that C/EBPbeta can compensate for the loss of C/EBPalpha if its concentration is induced to appropriate levels. Cyclic AMP 48-52 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 17-27 9334201-9 1997 We conclude that C/EBPalpha is required for the cAMP induction of PEPCK gene expression in the liver and that C/EBPbeta can compensate for the loss of C/EBPalpha if its concentration is induced to appropriate levels. Cyclic AMP 48-52 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 66-71